neurogenetics

, Volume 10, Issue 3, pp 199–208

Association between migraine and a functional polymorphism at the dopamine β-hydroxylase locus

Authors

  • F. Fernandez
    • Genomics Research Centre, Griffith Institute for Health and Medical ResearchGriffith University
  • N. Colson
    • Genomics Research Centre, Griffith Institute for Health and Medical ResearchGriffith University
  • S. Quinlan
    • Genomics Research Centre, Griffith Institute for Health and Medical ResearchGriffith University
  • J. MacMillan
    • Queensland Clinical Genetics ServiceRoyal Children’s Hospital
  • R. A. Lea
    • Genomics Research Centre, Griffith Institute for Health and Medical ResearchGriffith University
    • Institute of Environmental Science and Research
    • Genomics Research Centre, Griffith Institute for Health and Medical ResearchGriffith University
Original Article

DOI: 10.1007/s10048-009-0176-2

Cite this article as:
Fernandez, F., Colson, N., Quinlan, S. et al. Neurogenetics (2009) 10: 199. doi:10.1007/s10048-009-0176-2

Abstract

Migraine is a common neurological disorder with a significant genetic component. Although a number of linkage and association studies have been undertaken, the number and identity of all migraine susceptibility genes has yet to be defined. The existence of dopaminergic hypersensitivity in migraine has been recognised on a pharmacological basis and some studies have reported genetic association between migraine and dopamine-related gene variants. Our laboratory has previously reported association of migraine with a promoter STR marker in the dopamine beta hydroxylase (DBH) gene. In the present study, we analysed two additional DBH markers in two independent migraine case–control cohorts. These two markers are putative functional SNPs, one within the promoter (−1021C→T) and another SNP (+1603C→T) in exon 11 of the DBH gene. The results showed a significant association for allelic and genotypic frequency distribution between the DBH marker in the promoter and migraine in the first (P = 0.004 and P = 0.012, respectively) and the second (P = 0.013 and P = 0.031, respectively) tested cohorts. There was no association observed between either genotype and/or allelic frequencies for the DBH marker located in exon 11 and migraine (P ≥ 0.05). The promoter DBH marker, reported associated with migraine in this study, has been shown to affect up to 52% of plasma DBH activity. Varying DBH activity levels have been postulated to be involved in migraine process with an increase of dopamine, resulting from a lower DBH activity shown positively correlated with migraine severity. It is plausible that the functional promoter variant of DBH may play a role in the migraine disorder.

Keywords

Migraine Genetic association DBH gene Functional polymorphism

Copyright information

© Springer-Verlag 2009