Abstract
The minimal cardiopulmonary bypass (mini-CPB) circuit, a closed system with neither cardiotomy suction nor an open venous reservoir and thus no air–blood interface, reportedly reduces blood loss and inflammatory reactions associated with coronary bypass surgery. We evaluated the inflammatory reactions in patients in whom coronary bypass operations were performed with conventional CPB or mini-CPB (n = 15 each). Interleukin (IL)-6, IL-8, and neutrophil elastase levels; the neutrophil count; and the C-reactive protein value were measured before and immediately after surgery and on postoperative days 1 and 2. In addition, intraoperative blood loss and the transfusion volume were evaluated in these groups. Neutrophil elastase levels were lower in the mini-CPB group than in the conventional group on postoperative days 1 (127 ± 52 vs. 240 ± 100 µg/l, P = 0.013) and 2 (107 ± 17 vs. 170 ± 45 µ/l, P = 0.0001), as was the IL-8 level on postoperative day 1 (8.3 ± 6.4 vs. 19 ± 11 pg/ml, P = 0.016). The intraoperative blood loss and transfusion volumes were significantly lower in the mini-CPB group than in the conventional group (510 ± 244 vs. 1046 ± 966 ml, P = 0.012, and 691 ± 427 vs. 1416 ± 918 ml, P = 0.0033). Thus, mini-CPB appears to attenuate neutrophil activation and cytokine release after coronary bypass surgery and, in addition, has some beneficial effects on blood conservation.
Similar content being viewed by others
References
B Frering I Philip M Dehoux C Rolland JM Lanqlois JM Desmonts (1994) ArticleTitleCirculatory cytokines in patients undergoing normothermic cardiopulmonary bypass J Thorac Cardiovasc Surg 108 636–641 Occurrence Handle7934096 Occurrence Handle1:STN:280:ByqD3Mbntlw%3D
S Westaby (1987) ArticleTitleOrgan dysfunction after cardiopulmonary bypass. A systemic inflammatory reaction initiated by the extracorporeal circuit Intensive Care Med 13 89–95 Occurrence Handle3553271 Occurrence Handle10.1007/BF00254791 Occurrence Handle1:STN:280:BiiC1MrotFI%3D
A Philipp M Foltan A Thrum (2002) ArticleTitleMECC – a minimal ECC system for coronary artery bypass procedures J Extracorp Technol 34 A215
C Wiesenack A Liebold A Philipp M Ritzka J Koppenberg DE Birnbaum C Keyl (2004) ArticleTitleFour years' experience with a miniaturized extracorporeal circulation system and its influence on clinical outcome Artif Organs 28 1082–1088 Occurrence Handle15554936 Occurrence Handle10.1111/j.1525-1594.2004.00030.x
JP Remadi P Marticho I Butoi Z Ratokoarivelo F Trojette A Benamar S Beloucif D Foure H Poulain (2004) ArticleTitleClinical experience with the mini-extracorporeal circulation system: An evolution or a revolution? Ann Thorac Surg 77 2172–2176 Occurrence Handle15172290 Occurrence Handle10.1016/S0003-4975(03)00977-9
HM Nathoe D van Dijk EWL Jansen WJL Suyker JC Diephuis WJ Van Boven AB de la Riviere C Borst CJ Kalkman DE Grobbee E Buskens PPT de Jaeger (2003) ArticleTitleA comparison of on-pump and off-pump coronary bypass surgery in low-risk patients N Engl J Med 348 394–402 Occurrence Handle12556542 Occurrence Handle10.1056/NEJMoa021775
Y Formes D Gaillard O Ponzio M Chauffert MF Gerhardt P Deleuze OM Bical (2002) ArticleTitleReduction of the inflammatory response following coronary artery bypass grafting with total minimal extracorporeal circulation Eur J Cardiothorac Surg 22 527–533 Occurrence Handle10.1016/S1010-7940(02)00372-X
JPAM Schoenberger PAM Everts JJ Hoffmann (1995) ArticleTitleSystemic blood activation with open and closed venous reservoirs Ann Thorac Surg 59 1549–1555 Occurrence Handle10.1016/0003-4975(95)00241-C
SL Kunkel T Standiford K Kasahara RM Strieter (1991) ArticleTitleInterleukin-8 (IL-8): The major neutrophil chemotactic factor in the lung Exp Lung Res 17 17–23 Occurrence Handle2013270 Occurrence Handle1:CAS:528:DyaK3MXmtVGhsbc%3D
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Ohata, T., Mitsuno, M., Yamamura, M. et al. Minimal cardiopulmonary bypass attenuates neutrophil activation and cytokine release in coronary artery bypass grafting. J Artif Organs 10, 92–95 (2007). https://doi.org/10.1007/s10047-007-0377-0
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10047-007-0377-0