Abstract
For efficient removal of large molecular weight solutes by dialysis, several types of internal filtration-enhancing dialyzers (IFEDs) are commercially available. However, in a pressure-driven membrane separation process (i.e., filtration), membrane fouling caused by adhesion of plasma proteins is a severe problem. The objective of the present study is to investigate the effects of internal filtration on membrane fouling based on the membrane's pure-water permeability, diffusive permeability, and sieving coefficient. Hemodialysis experiments were performed with two different dialyzers, IFEDs and non-IFEDs. Local membrane fouling in each dialyzer was evaluated by measuring the pure-water permeability, the diffusive permeability, and the sieving coefficient of native membranes and membranes treated with bovine blood. The effects of packing ratio on dialysate flow pattern were also evaluated by measuring the time required for an ion tracer to reach electrodes placed in the dialyzers. In the IFED, membrane fouling caused by protein adhesion is increased because of enhanced internal filtration only at the early stage of dialysis, and this fouling tends to occur only near the dialysate outlet port. However, enhanced internal filtration has little effect on measured membrane transfer parameters.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
M Mineshima T Hoshino K Era T Agishi K Ota (1987) ArticleTitleDiffusive and convective mass transport characteristics in S615382-MG removal Trans ASAIO 33 103–106
KH Stiller H Mann H Brunner (1985) ArticleTitleBackfiltration in hemodialysis with highly permeable membranes Contr Nephrol 46 23–32
U Baurmeister J Vienken V Daum (1989) ArticleTitleHigh-flux dialysis membranes: endotoxin transfer by backfiltration can be a problem Nephrol Dial Transplant 4 89–93
BJG Preira B Snodgrass PJ Hogan AJ King (1995) ArticleTitleDiffusive and convective transfer of cytokine-inducing bacterial products across hemodialysis membranes Kidney Int 47 603–610
B Canaud JY Bose H Leray F Stec A Argiles M Leblanc C Mion (1998) ArticleTitleOn-line haemodiafiltration: state of the art Nephrol Dial Transplant 13 3–11
F Dellanna A Wuepper CA Baldamus (1996) ArticleTitleInternal filtration – advantage in haemodialysis? Nephrol Dial Transplant 11 Suppl 2 83–66
N Hosoya M Sasaki S Takesawa (1995) ArticleTitleEvaluation of a new dialyzer that can substitute much fluid—the plug dialyzer Jpn J Artif Organs 24 664–669
M Mineshima I Ishimori K Ishida T Hoshino I Kaneko Y Sato T Agishi N Tamamura H Sakurai T Masuda H Hattori (2000) ArticleTitleEffects of internal filtration on the solute removal efficiency of a dialyzer ASAIO J 46 456–460
C Ronco A Brendolan M Feriani M Milan P Conz A Lupi P Berto M Bettini G La Greca (1992) ArticleTitleA new scintigraphic method to characterize ultrafiltration in hollow fiber dialyzers Kidney Int 41 1383–1393
Y Sato M Mineshima I Ishimori I Kaneko T Akiba S Teraoka (2003) ArticleTitleEffect of hollow fiber length on solute removal and quantification of internal filtration rate by Doppler ultrasound Int J Artif Organs 26 129–134
T Fujimura Y Uchi M Fukuda M Miyazaki S Uezumi T Hiyoshi (2004) ArticleTitleDevelopment of a dialyzer with enhanced internal filtration to increase the clearance of low molecular weight proteins J Artif Organs 7 149–154
JK Leypoldt RP Frigon LW Henderson (1983) ArticleTitleDextran sieving coefficients of hemofiltration membranes ASAIO Trans 29 678–683
E Matthiasson (1983) ArticleTitleThe role of macromolecular adsorption in fouling of ultrafiltration membranes J Membr Sci 16 23–36
J Paris P Guchardon F Charbit (2002) ArticleTitleTransport phenomena in ultrafiltration: a new two-dimensional model compared with classical models J Membr Sci 207 43–58
D Belhocine H Grib D Abdessmed Y Comeau N Mameri (1998) ArticleTitleOptimization of plasma protein concentration by ultrafiltration J Membr Sci 142 159–171
A Rockel J Hertel P Fiegel S Abdelhamid N Panitz D Walb (1986) ArticleTitlePermeability and secondary membrane formation of a high-flux poysulfone hemofilter Kidney Int 30 429–432
T Kanamori K Sakai T Awaka M Fukuda (1994) ArticleTitleMass transfer in laminar flows around single hollow-fiber membranes for hemodialysis J Chem Eng Jpn 27 830–832
S Takesawa K Ozawa R Mimura K Sakai (1984) ArticleTitleMechanism of membrane permeability of solute in the dialyzer Jpn J Artif Organs 13 1460–1467
T Ohmura T Tatsuguchi J Nishikido T Yamamoto F Fushimi O Nishida K Sakai (1989) ArticleTitleA new method of determining the solute permeability of hollow-fiber dialysis membranes by means of laser light traveling along optic fiber Trans ASAIO 35 601–603
T Kanamori K Sakai T Awaka M Fukuda (1994) ArticleTitleAn improvement on the method of determining the solute permeability of hollow-fiber dialysis membranes photometrically using optical fibers and comparison of the method with ordinary techniques J Membr Sci 88 159–165
FJ Stevenson (1974) ArticleTitleUnsteady mass transfer in a long composite cylinder with interfacial resistances AIChE J 20 461–466
FJ Stevenson (1975) ArticleTitleAn unsteady state method for measuring the permeability of small tubular membranes AIChE J 12 1192–1199
K Ishiwata K Yamamoto F Kohori K Sakai M Fukuda T Hiyoshi (2002) ArticleTitleTechnical evaluation of dialysate flow in a hollow-fiber dialyzer J Artif Organs 5 251–256
P Valette M Thomas P Dejardin (1999) ArticleTitleAdsorption of low molecular weight proteins to hemodialysis membranes: experimental results and simulations Biomaterials 20 1621–1634
H Brenner H Mann S Stiller HG Sieberth (1985) ArticleTitlePermeability for middle and higher molecular weight substances Contrib Nephrol 46 33–42
T Bosch B Schmidt W Samtleben HJ Gurland (1985) ArticleTitleEffect of protein absorption on diffusive and convective transport through polysulfone membranes Contrib Nephrol 46 14–22
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Yamamoto, Ki., Hiwatari, M., Kohori, F. et al. Membrane fouling and dialysate flow pattern in an internal filtration-enhancing dialyzer. J Artif Organs 8, 198–205 (2005). https://doi.org/10.1007/s10047-005-0303-2
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/s10047-005-0303-2