Abstract
Graphene nanosheets were directly electrodeposited onto a glassy carbon electrode (GCE) from the electrolyte solution containing graphene oxide (GO); the resulting electrode (ED-GO/GCE) was characterized with scanning electron microscopy. A simple and rapid electrochemical method was developed for the determination of theophylline (TP), based on the excellent properties of ED-GO film. The result indicated that ED-GO film-modified GCE exhibited efficient electrocatalytic oxidation for TP with relatively high sensitivity and stability. The electrochemical behavior of TP at ED-GO/GCE was investigated in detail. Under the optimized conditions, the oxidation peak current was proportional to the TP concentration in the range of 8.0 × 10−7 to 6.0 × 10−5 mol L−1 with the detection limit of 1.0 × 10−7 mol L−1 (S/N = 3). The proposed method was successfully applied to green tea samples with satisfactory results.
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References
Pumera M (2010) Graphene-based nanomaterials and their electrochemistry. Chem Soc Rev 39:4146–4157
Chen D, Tang LH, Li JH (2010) Graphene-based materials in electrochemistry. Chem Soc Rev 39:3157–3180
Wang Y, Li YM, Tang LH, Lu J, Li JH (2009) Application of graphene-modified electrode for selective detection of dopamine. Electrochem Commun 11:889–892
Shao YY, Wang J, Wu H, Liu J, Aksay IA, Lin YH (2010) Graphene based electrochemical sensors and biosensors: a review. Electroanalysis 22:1027–1036
Lu JJ, Liu SQ, Ge SG, Yan M, Yu JH, Hu XT (2012) Ultrasensitive electrochemical immunosensor based on Au nanoparticles dotted carbon-nanotube-graphene composite and functionalized mesoporous materials. Biosens Bioelectron 33:29–35
Novoselov KS, Jiang D, Schedin F, Booth TJ, Khotkevich VV, Morozov SV, Geim AK (2005) Two-dimensional atomic crystals. Proc Natl Acad Sci USA 102:10451–10453
Geim AK, Novoselov KS (2007) The rise of graphene. Nat Mater 6:183–191
Berger C, Song Z, Li X, Wu X, Brown N, Naud C, Mayou D, Li T, Hass J, Marchenkov AN, Conrad EH, First PN, De Heer WA (2006) Electronic confinement and coherence in patterned epitaxial graphene. Science 312:1191–1196
Sutter PW, Flege JI, Sutter EA (2008) Epitaxial graphene on ruthenium. Nat Mater 7:406–411
Dato A, Radmilovic V, Lee Z, Phillips J, Frenklach M (2008) Substrate-free gas-phase synthesis of graphene sheets. Nano Lett 8:2012–2016
Stankovich S, Dikin DA, Piner RD, Kohlhaas KA, Kleinhammes A, Jia YY, Wu Y, Nguyen ST, Ruoff RS (2007) Synthesis of graphene-based nanosheets via chemical reduction of exfoliated graphite oxide. Carbon 45:1558–1565
Si YC, Samulski ET (2008) Synthesis of water soluble graphene. Nano Lett 8:1679–1682
Hernandez Y, Nicolosi V, Lotya M, Blighe FM, Sun ZY, De S, McGovern IT, Holland B, Byrne M, Gun’ko YK, Boland JJ, Niraj P, Duesberg G, Krishnamurthy S, Goodhue R, Hutchison J, Scardaci V, Ferrari AC, Coleman JN (2008) High-yield production of graphene by liquid-phase exfoliation of graphite. Nat Nanotech 3:563–568
Guo HL, Wang XF, Qian QY, Wang FB, Xia XH (2009) A green approach to the synthesis of graphene nanosheets. ACS Nano 3:2653–2659
Shao YY, Wang J, Engelhard M, Wang CM, Lin YH (2010) Facile and controllable electrochemical reduction of graphene oxide and its applications. J Mater Chem 20:743–748
Zhou M, Wang YL, Zhai YM, Zhai JF, Ren W, Wang F, Dong SJ (2009) Controlled synthesis of large-area and patterned electrochemically reduced graphene oxide films. Chem Eur J 15:6116–6120
Chen LY, Tang YH, Wang K, Liu CB, Luo SL (2011) Direct electrodeposition of reduced graphene oxide on glassy carbon electrode and its electrochemical application. Electrochem Commun 13:133–137
Hilder M, Winther-Jensen B, Li D, Forsyth M, MacFarlane DR (2011) Direct electro-deposition of grapheme from aqueous suspensions. Phys Chem Chem Phys 13:9187–9193
Aresta A, Palmisano F, Zambonin CG (2005) Simultaneous determination of caffeine, theobromine, theophylline, paraxanthine and nicotine in human milk by liquid chromatography with diode array UV detection. Food Chem 93:177–181
Spātaru N, Sarada BV, Tryk DA, Fujishima A (2002) Anodic voltammetry of xanthine, theophylline, theobromine and caffeine at conductive diamond electrodes and its analytical application. Electroanalysis 14:721–728
Zwillich CW, Sutton FD, Neff TA, Cohn WM, Matthay RA, Weinberger MM (1975) Theophylline-induced seizures in adults. Ann Intern Med 82:784–787
Chen QS, Guo ZM, Zhao JW (2008) Identification of green tea's (Camellia sinensis (L.)) quality level according to measurement of main catechins and caffeine contents by HPLC and support vector classification pattern recognition. J Pharm Biomed Anal 48:1321–1325
Bellia V, Battaglia S, Matera MG, Cazzola M (2006) The use of bronchodilators in the treatment of airway obstruction in elderly patients. Pharmacol Ther 19:311–319
Nicholso RS (1965) Theory and application of cyclic voltammetry for measurement of electrode reaction kinetics. Anal Chem 37:1351–1355
Shang NG, Papakonstantinou P, McMullan M, Chu M, Stamboulis A, Potenza A, Dhesi SS, Marchetto H (2008) Catalyst-free efficient growth, orientation and biosensing properties of multilayer graphene nanoflake films with sharp edge planes. Adv Funct Mater 18:3506–3514
Chen PH, Fryling MA, McCreery RL (1995) Electron transfer kinetics at modified carbon electrode surfaces: the role of specific surface. Anal Chem 67:3115–3122
Tang LH, Wang Y, Li YM, Feng HB, Lu J, Li JH (2009) Preparation, structure, and electrochemical properties of reduced graphene sheet films. Adv Funct Mater 19:2782–2789
Hou SF, Kasner ML, Su SJ, Patel K, Cuellari R (2010) Highly sensitive and selective dopamine biosensor fabricated with silanized graphene. J Phys Chem C 114:14915–14921
Wang GX, Wang B, Park J, Yang J, Shen XP, Yao J (2009) Synthesis of enhanced hydrophilic and hydrophobic graphene oxide nanosheets by a solvothermal method. Carbon 47:68–72
Stankovich S, Piner RD, Chen XQ, Wu NQ, Nguyen ST, Ruoff RS (2006) Stable aqueous dispersions of graphitic nanoplatelets via the reduction of exfoliated graphite oxide in the presence of poly (sodium 4-styrenesulfonate). J Mater Chem 16:155–158
Boukhvalov DW, Katsnelson MI (2008) Modeling of graphite oxide. J Am Chem Soc 130:10697–10701
Brunetti B, Desimoni E, Casati P (2007) Determination of caffeine at a Nafion-covered glassy carbon electrode. Electroanalysis 19:385–388
Hansen BH, Dryhurst G (1971) Electrochemical oxidation of theophylline at the pyrolytic graphite electrode. J Electroanal Chem 32:405–414
Hansen BH, Dryhurst G (1971) Electrochemical oxidation of theobromine and caffeine at the pyrolytic graphite electrode. J Electroanal Chem Interface Electrochem 30:407–416
Liu LQ, Xiao F, Li JW, Wu WB, Zhao FQ, Zeng BZ (2008) Platinum nanoparticles decorated multiwalled carbon nanotubes-ionic liquid composite film coated glassy carbon electrodes for sensitive determination of theophylline. Electroanalysis 20:1194–1199
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This project was supported by the National Natural Science Foundation of China (grant no. 20975061).
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Cui, F., Zhang, X. A method based on electrodeposition of reduced graphene oxide on glassy carbon electrode for sensitive detection of theophylline. J Solid State Electrochem 17, 167–173 (2013). https://doi.org/10.1007/s10008-012-1867-4
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DOI: https://doi.org/10.1007/s10008-012-1867-4