Skip to main content

Advertisement

SpringerLink
Log in

Papillary cystadenoma of the lower lip exhibiting ciliated pseudostratified columnar epithelium: report of a bizarre case and review of the literature

  • Review Article
  • Published:
Oral and Maxillofacial Surgery Aims and scope Submit manuscript

Abstract

Background

Salivary gland tumors are uncommon and constitute 2–6.5 % of all head and neck neoplasms. Tumors of minor salivary gland origin account for less than 25 % of all salivary gland neoplasms. Papillary cystadenoma of salivary glands is a rare benign epithelial neoplasm characterized by multicystic growth in which the epithelium exhibits adenomatous proliferation. Papillary cystadenoma of minor salivary glands most frequently involves the lip, buccal mucosa, and palate. This tumor typically presents as a slow-growing, painless mass, usually with diameter of less than 1 cm and clinical resemblance to a mucocele. Although most papillary cystadenomas are predominantly of one cell type, a regional variability may be present.

Case Report

We present a case of papillary cystadenoma of the minor salivary glands in a 58-year-old patient exhibiting an upper respiratory tract epithelium, a profoundly atypical benign tumor.

Discussion

This type of minor salivary gland tumor epithelium in the lower lip may be the result of a metaplastic process or simply another neoplastic manifestation of papillary cystadenoma. As far as the differential diagnosis of this entity is concerned, it is important to distinguish it from papillary cystadenoma lymphomatosum (Warthin's tumor), low-grade mucoepidermoid carcinoma, the papillary-cystic variant of acinic cell carcinoma, and cystadenocarcinoma Recognition of this lesion is important for the clinician since the differential diagnosis includes lesions with similar clinical appearance and infiltrative behavior.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Auclair PL, Ellis GL, Gnepp DR, Wenig BM, Janney CG (1991) Salivary gland neoplasms: general considerations. In: Ellis GL, Auclair PL, Gnepp DR (eds) Surgical Pathology of the Salivary Glands. W.B. Saunders Co, Philadelphia, pp 135–164

    Google Scholar 

  2. Alexis JB, Dembrow V (1995) Papillary cystadenoma of a minor salivary gland. J Oral Maxillofac Surg 53(1):70–72

    Article  PubMed  CAS  Google Scholar 

  3. Skalova A, Michal M (2005) Cystadenoma. In: Barnes L, Eveson JW, Reichart P, et al.,eds. World Health Organization Classification of Tumors of Tumors: pathology and genetics of tumors of the head and neck. Lyon: IARC pp 273-274

  4. Auclair PL, Ellis GL, Gnepp DR (1991) Other benign epithelial neoplasms. In: Ellis GL, Auclair PL, Gnepp DR (eds) Surgical pathology of the salivary glands. Saunders, Philadelphia, pp 252–268

    Google Scholar 

  5. Ellis GL, Auclair PL (1996) Cystadenoma. In: Atlas of tumor pathology: tumors of the salivary glands. 3rd series, fascicle 17. Washington DC: Armed Forces Institute of Pathology pp 115-120

  6. Ribeiro DA, Costa MR, de Assis GF (2004) Papillary cystadenoma of the minor salivary gland of the lower lip. Dermatol Online J 10(1):14

    PubMed  Google Scholar 

  7. Mahler V, Schell H (1999) Papillary cystadenoma: a rare tumor of the minor salivary glands. Eur J Dermatol 9(5):387–389

    PubMed  CAS  Google Scholar 

  8. Lim CS, Ngu I, Collins AP, McKellar GM (2008) Papillary cystadenoma of a minor salivary gland: report of a case involving cytological analysis and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 105(1):e28–e33

    Article  PubMed  Google Scholar 

  9. Eveson JW, Nagao T (2009) Cystadenoma. In: Diseases of the salivary glands. In: Barnes L eds: Surgical pathology of the head and neck 3rd ed. New York: Informa Healthcare pp 538-540

  10. Waldron CA, El-Mofty SK, Gnepp DR (1988) Tumors of the intraoral minor salivary glands: a demographic and histologic study of 426 cases. Oral Surg 66:323–333

    Article  PubMed  CAS  Google Scholar 

  11. Callego L, Junquera L, Fresno MF, De Vicente HC (2008) Papillary cystadenoma and cystadenocarcinoma of salivary glands: two unusual entities. Med Oral Pathol Oral Cir Bucal 13(7):460–463

    Google Scholar 

  12. Matsuzaka K, Kokubu E, Takeda E et al (2003) Papillary cystadenoma arising from the upper lip: a case report. Bull Tokyo dent 44:213–216

    Article  Google Scholar 

  13. Tsurumi K, Kamiya H, Yokoi M, Kameyama Y (2003) Papillary oncocytic cystadenoma of palatal minor salivary gland: a case report. J Oral Maxillofac Surg 61:631–633

    Article  PubMed  Google Scholar 

  14. Seifert G (1991) Histologic typing of salivary gland tumors (2nd ed). New York, NY, Springer pp 16-17

  15. Chaudhry AP, Vickers RA, Gorlin RJ (1961) Intraoral minor salivary gland tumors: an analysis of 1414 cases. Oral Surg Oral Med Oral Pathol 14:1194–1126

    Article  PubMed  CAS  Google Scholar 

  16. Guccion JG, Redman RS, Calhoun NR et al (1997) Papillary cystadenoma of the palate: a case report and ultrastructural study. J Oral Maxillofac Surg 55:759–764

    Article  PubMed  CAS  Google Scholar 

  17. Toida M, Shimokawa K, Makita H et al (2005) Intraoral minor salivary gland tumors: a clinicopathological study of 82 cases. Int J Oral Maxillofac Surg 34:528–532

    Article  PubMed  CAS  Google Scholar 

  18. Cohen MA, Batsakis JG (1968) Oncocytic tumors (oncocytomas) of minor salivary glands. Arc Otolaryngol 88:71–73

    Article  CAS  Google Scholar 

  19. Zhou QW, Gao JP, Wu B, Zhou SS (2003) Papillary cystadenoma of the epididymis accompanied by testicular atrophy: a case report. Zhonghua Nan Ke Xue 9:389–390

    PubMed  Google Scholar 

  20. Fatum M, Rojansky N, Shushan A (2001) Papillary serous cystadeno-fibroma of the ovary—is it really so rare? Int J Gynaecol Obstet 75:85–86

    Article  PubMed  CAS  Google Scholar 

  21. Davidov MI, Ponomareva TB, Liadov AA (2003) Multiple bilateral papillary cystadenoma of the kidney. Urologiia 3:60–61

    PubMed  Google Scholar 

  22. Masi JD, Hoang K, Sawyer R (1986) Sialadenoma papilliferum of the adenoids in a 2-year-old child. Arch Pathol Lab Med 110:558

    PubMed  CAS  Google Scholar 

  23. Warnock GR (1991) Papillary cystadenoma lymphomatosum (Warthin's tumor). In: Ellis GL, Auclair PL, Gnepp DR (eds) Surgical pathology of the salivary glands. W.B. Saunders Co, Philadelphia, pp 187–201

    Google Scholar 

  24. Gorlin RJ (1957) Potentialities of oral epithelium manifest by mandibular dentigerous cysts. Oral Surg Oral Med Oral Pathol 10(3):271–284

    Article  PubMed  CAS  Google Scholar 

  25. Waldron CA (1995) Odontogenic cysts and tumors. In: Neville B, Damm D, Allen C, Bouquot J (eds) Oral and maxillofacial pathology. WB Saunders, Philadelphia, pp 493–540

    Google Scholar 

  26. Boffano P, Zavattero E, Campisi P, Gallesio C (2009) Surgical treatment of an oral cyst with respiratory epithelium. J Craniofac Surg 20(4):1275–1277

    Article  PubMed  Google Scholar 

  27. Cohen MB, Liung BM, Boles R (1988) Salivary gland tumors. Fine needle aspiration versus frozen section diagnosis. Arch Otolaryngol Head Neck Surg 112:867–869

    Article  Google Scholar 

  28. Orell SR, Nette WJ (1988) Fine needle aspiration of salivary gland tumors. Problems and pitfalls. Pathology 20:332–337

    Article  PubMed  CAS  Google Scholar 

  29. Adibfar A, Mintz SM (1994) Papillary cystadenoma lymphomatosum of the upper lip: report of case. J Oral Maxillofac Surg 52:183–185

    Article  PubMed  CAS  Google Scholar 

  30. Foss RD, Ellis GL, Auclair PL (1996) Salivary gland cystadenocarcinomas. A clinicopathologic study of 57 cases. Am J Surg Pathol 20(12):1440–1447

    Article  PubMed  CAS  Google Scholar 

Download references

Conflict of interest

The authors of this paper declare that they have no conflict of interest.

Author information

Authors and Affiliations

  1. Department of Oral and Maxillofacial Surgery, Southern General Hospital of Glasgow, 65 Maxwell Drive, Pollokshields, G41 5JF, Glasgow, UK

    Panagiotis Stathopoulos

  2. Oral Medicine Clinic, A. Syggros Hospital of Dermatologic and Venereal Diseases, Department of Dermatology, School of Medicine, University of Athens, Kifissias Av 176 & Veaki 1St, Athens, 1152, Greece

    Eleni Gagari

Authors
  1. Panagiotis Stathopoulos
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Eleni Gagari
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Panagiotis Stathopoulos.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Stathopoulos, P., Gagari, E. Papillary cystadenoma of the lower lip exhibiting ciliated pseudostratified columnar epithelium: report of a bizarre case and review of the literature. Oral Maxillofac Surg 17, 161–164 (2013). https://doi.org/10.1007/s10006-012-0357-2

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10006-012-0357-2

Keywords

Search

Navigation