European Child & Adolescent Psychiatry

, Volume 19, Issue 3, pp 199–210

From nature versus nurture, via nature and nurture, to gene × environment interaction in mental disorders

  • Anne-Kathrin Wermter
  • Manfred Laucht
  • Benno G. Schimmelmann
  • Tobias Banaschweski
  • Edmund J. S. Sonuga-Barke
  • Marcella Rietschel
  • Katja Becker
Review

DOI: 10.1007/s00787-009-0082-z

Cite this article as:
Wermter, AK., Laucht, M., Schimmelmann, B.G. et al. Eur Child Adolesc Psychiatry (2010) 19: 199. doi:10.1007/s00787-009-0082-z

Abstract

It is now generally accepted that complex mental disorders are the results of interplay between genetic and environmental factors. This holds out the prospect that by studying G × E interplay we can explain individual variation in vulnerability and resilience to environmental hazards in the development of mental disorders. Furthermore studying G × E findings may give insights in neurobiological mechanisms of psychiatric disorder and so improve individualized treatment and potentially prevention. In this paper, we provide an overview of the state of field with regard to G × E in mental disorders. Strategies for G × E research are introduced. G × E findings from selected mental disorders with onset in childhood or adolescence are reviewed [such as depressive disorders, attention-deficit/hyperactivity disorder (ADHD), obesity, schizophrenia and substance use disorders]. Early seminal studies provided evidence for G × E in the pathogenesis of depression implicating 5-HTTLPR, and conduct problems implicating MAOA. Since then G × E effects have been seen across a wide range of mental disorders (e.g., ADHD, anxiety, schizophrenia, substance abuse disorder) implicating a wide range of measured genes and measured environments (e.g., pre-, peri- and postnatal influences of both a physical and a social nature). To date few of these G × E effects have been sufficiently replicated. Indeed meta-analyses have raised doubts about the robustness of even the most well studied findings. In future we need larger, sufficiently powered studies that include a detailed and sophisticated characterization of both phenotype and the environmental risk.

Keywords

Gene–environment interactionDepressive disordersADHDObesitySchizophreniaSubstance use disorders

Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Anne-Kathrin Wermter
    • 1
  • Manfred Laucht
    • 2
  • Benno G. Schimmelmann
    • 3
  • Tobias Banaschweski
    • 2
  • Edmund J. S. Sonuga-Barke
    • 4
    • 5
  • Marcella Rietschel
    • 6
  • Katja Becker
    • 1
    • 2
  1. 1.Department of Child and Adolescent Psychiatry and PsychotherapyPhilipps-University of MarburgMarburgGermany
  2. 2.Department of Child and Adolescent Psychiatry and PsychotherapyCentral Institute of Mental HealthMannheimGermany
  3. 3.University Hospital of Child and Adolescent Psychiatry, University of BernBernSwitzerland
  4. 4.Developmental Brain-Behaviour Laboratory, Department of PsychologyUniversity of SouthamptonSouthamptonUK
  5. 5.Department of Experimental Clinical and Health PsychologyUniversity of GentGhentBelgium
  6. 6.Division of Genetic Epidemiology in PsychiatryCentral Institute of Mental HealthMannheimGermany