References
Zukawa M, Nakano M, Hirano N, Mizuhashi K, Kanamori M. The effectiveness of gefitinib on spinal metastases of lung cancer—report of two cases. Asian Spine J. 2008;2:109–13.
Yamashita Y, Aoki T, Hanagiri T, Yoshii C, Mukae H, Uramoto H, Korogi Y. Osteosclerotic lesions in patients treated with gefitinib for lung adenocarcinomas: a sign of favorable therapeutic response. Skelet Radiol. 2012;41:409–14.
Kijima T, Fujii Y, Suyama T, Okubo Y, Yonese J, Fukui I. Lung and bone metastases from renal cell carcinoma responsive to bisphosphonates: a case report. Int J Urol. 2008;15:546–7.
Osanai T, Tsuchiya T, Ogino T, Nakahara K. Long-term prevention of skeletal complications by pamidronate in a patient with bone metastasis from endometrial carcinoma: a case report. Gynecol Oncol. 2006;100:195–7.
Normanno N, De Luca, Aldinucci D, Maiello MR, Mancino M, D’Antonio A, De Filippi R, Pinto A. Gefitinib inhibits the ability of human bone marrow stromal cells to reduce osteoclast differentiation; implications for the pathologenesis and treatment of bone metastasis. Endocr Ralat Cancer. 2005;12:471–82.
Normanno N, Gullick WJ. Epidermal growth factor receptor tyrosine kinase inhibitors and bone metastases: different mechanisms of action for a novel therapeutic application? Endocr Relat Cancer. 2006;13:3–6.
Mitsudomi T, Yatabe Y. Mutations of the epidermal growth factor receptor gene and related genes as determinants of epidermal growth factor receptor tyrosine kinase inhibitors sensitivity in lung cancer. Cancer sci. 2007;98:1817–24.
Clézardin P, Fournier P, Boissier S, Peyruchaud O. In vitro and in vivo antitumor effects of bisphosphonates. Curr Med Chem. 2003;10:173–80.
Koto K, Horie N, Kimura S, Murata H, Sakabe T, Matsui T, Watanabe M, Adachi S, Maekawa T, Fushiki S, Kubo T. Clinically relevant dose of zoledronic acid inhibits spontaneous lung metastasis in a murine osteosarcoma model. Cancer Lett. 2009;274:271–8.
Koto K, Murata H, Kimura S, Horie N, Matsui T, Nishigaki Y, Ryu K, Sakabe T, Ashihara E, Maekawa T, Fushiki S, Kubo T. Zoledronic acid inhibits proliferation of human fibrosarcoma cells with induction of apoptosis, and shows combined effects with other anticancer agents. Oncol Rep. 2010;24:233–9.
Krempien R, Huber PE, Harms W, Treiber M, Wannenmacher M, Krempien B. Combination of early bisphosphonate administration and irradiation leads to improved remineralization and restabilization of osteolytic bone metastases in an animal tumor model. Cancer. 2003;98:1318–24.
Kijima T, Fujii Y, Suyama T, Okubo Y, Yamamoto S, Masuda H, Yonese J, Fukui I. Radiotherapy to bone metastases from renal cell carcinoma with or without zoledronate. BJU Int. 2009;103:620–4.
Ricciardi S, de Marinis F. Treatment of bone metastases in lung cancer: the actual role of zoledronic acid. Rev Recent Clin Trials. 2009;4:205–11.
Moore KL, Persaud TVN, Torchia MG. Skeletal system. The developing human. 9th ed. Philadelphia: Elsevier; 2013. p. 343–61.
Kierszenbaum AL, Tres LL. Oeteogenesis. Histology and Cell Biology: an introduction to Pathology. 3rd ed. Philadelphia: Elsevier; 2012. p. 151–68.
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Kishimoto, Y., Iwase, T., Yano, T. et al. Reossification of osteolytic metastases at the acetabulum following gefitinib and multidisciplinary treatment for lung cancer: a case report with autopsy findings. J Orthop Sci 20, 914–918 (2015). https://doi.org/10.1007/s00776-014-0562-y
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DOI: https://doi.org/10.1007/s00776-014-0562-y