Serum 25-hydroxyvitamin D status in hip and spine-fracture patients in Japan
Purchase on Springer.com
$39.95 / €34.95 / £29.95*
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.
Serum 25-hydroxyvitamin D (25(OH)D) is used as an index that reflects the level of vitamin D. We have previously reported, on the basis of a study in Sado in Niigata, that patients with hip fracture have lower serum 25(OH)D levels than non-hip-fracture cases. In this study, the serum 25(OH)D status in hip-fracture cases was examined in four regions in Japan. Although most hip-fracture patients have experienced past spine-compression fractures, the relationship of these fractures and 25(OH)D is unknown. Therefore, we also examined the 25(OH)D level in spine-compression fracture patients in the same locations and time periods.
The levels of 25(OH)D, intact parathyroid hormone (intact PTH), undercarboxylated osteocalcin (ucOC), urine N-terminal crosslinking telopeptide of type I collagen (NTX), and bone mineral density were examined in patients with hip and spine fracture due to osteoporosis in several regions in Japan.
There were no significant differences in age, BMI, serum 25(OH)D, serum intact PTH, and serum ucOC among the regions. Levels of serum 25(OH)D were low in patients with hip fracture and spine fracture. The average serum 25(OH)D level was significantly lower in hip-fracture patients than in spine-fracture patients (16.3 vs. 18.1 ng/mL, P < 0.05). High serum ucOC was found in 37% of hip-fracture patients and 44% of spine-fracture patients.
Both hip and spine-fracture patients have vitamin D insufficiency, with similar results found in elderly patients in four areas of Japan. The severity of this condition tends to be more serious in hip-fracture patients than in spine-fracture patients.
- Morita Y, Endo N, Iga T, Tokunaga K, Ohkawa Y. The incidence of cervical and trochanteric fractures of the proximal femur in 1999 in Niigata Prefecture, Japan. J Bone Miner Metab. 2002;20(5):311–8. CrossRef
- Oinuma T, Sakuma M, Endo N. Secular change of the incidence of four fracture types associated with senile osteoporosis in Sado, Japan: the results of a 3-year survey. J Bone Miner Metab. 2010;28(1):55–9. CrossRef
- Nuti R, Martini G, Valenti R, Gambera D, Gennari L, Salvadori S, Avanzati A. Vitamin D status and bone turnover in women with acute hip fracture. Clin Orthop Relat Res. 2004;422:208–13. CrossRef
- LeBoff MS, Kohlmeier L, Hurwitz S, Franklin J, Wright J, Glowacki J. Occult vitamin D deficiency in postmenopausal US women with acute hip fracture. JAMA. 1999;281(16):1505–11. CrossRef
- Sakuma M, Endo N, Oinuma T, Hayami T, Endo E, Yazawa T, Watanabe K, Watanabe S. Vitamin D and intact PTH status in patients with hip fracture. Osteoporos Int. 2006;17:1608–14. CrossRef
- Nakamura K. Vitamin D insufficiency in Japanese populations: from the viewpoint of the prevention of osteoporosis. J Bone Miner Metab 2006;24(1):1–6 (Review).
- Okano T, Tsugawa N, Suhara Y, Tanaka K, Ishida H, Uenishi K, Kubota E, Fukunaga M, Hosoi T, Shiraki M. Vitamin D status and bone metabolic markers of adult, especially elderly women in Japan. Osteoporos Jpn 2004;12:76–79 (in Japanese).
- Hagino H, Yamamoto K, Ohshiro H, Nakamura T, Kishimoto H, Nose T. Changing Incidence of hip, distal radius and proximal humerus fractures in Tottori Prefecture, Japan. Bone (NY). 1999;24:265–70.
- Cummings S, Cauley J, Palermo L, Ross PD, Wasnich RD, Black D, Faulkner K. Racial difference in hip axis length might explain racial differences in rates of hip fracture. Osteoporos Int. 1994;4:226–9. CrossRef
- Kanis JA, Johnell O, De Leat C, Jonsson B, Oden A, Ogelsby AK. International variation in hip fracture probabilities : Implication for risk assessment. J Bone Miner Res. 2002;17:1237–44. CrossRef
- Hollis BW. Circulating 25-hydroxyvitamin D levels indicative of vitamin D sufficiency: implications for establishing a new effective dietary intake recommendation for vitamin D. J Nutr. 2005;135:317–22.
- Malabanan A, Veronikis E, Holick MF. Redefining vitamin D insufficiency. Lancet. 1998;351:805–6. CrossRef
- Need AG, Horowitz M, Morris HA, Nordin BC. Vitamin D status: effects on parathyroid hormone and 1,25-dihydroxyvitamin D in postmenopausal women. Am J Clin Nutr. 2000;71:1577–81.
- Yamaoka M, Inomata K, Wakiya S, Baba H, Yamashita H, Yamashita H, Noguchi S. Zenjidou denkikagaku hakkoumeneki sokuteisouchi “ECLusys 2010” ni yoru fukukoujousenn horumon sokutei no kentou. Jpn J Med Pharm Sci 2001;46(5):753–758 (in Japanese).
- Thomas L. Parathyroid hormone (PTH). Clinical laboratory diagnosis. 1st English ed. Frankfurt: TH-Books; 1998. pp. 248–250.
- Segersten U, Correa P, Hewison M, Hellman P, Dralle H, Carling T, Akerstrom G, Westin G. 25-Hydroxyvitamin D(3)-1alpha-hydroxylase expression in normal and pathological parathyroid glands. J Clin Endocrinol Metab. 2002;87(6):2967–72. CrossRef
- World Health Organization. Prevention and management of osteoporosis, technical report series 2003; No. 921, pp. 38–31.
- Tsugawa N, Shiraki M, Suhara Y, Kamao M, Ozaki R, Tanaka K, Okano T. Low plasma phylloquinone concentration is associated with high incidence of vertebral fracture in Japanese women. J Bone Miner Metab. 2008;26(1):79–85. CrossRef
- Shiraki M, Aoki C, Yamazaki N, Ito Y, Tsugawa N, Suhara Y, Okano T. Clinical assessment of undercarboxylated osteocalcin measurement in serum using an electrochemiluminescence immunoassay: Establishments of cut-off value to determine vitamin K insufficiency in bone and to predict fracture leading to clinical use of vitamin K2. Jpn J Med Pharm Sci 2007;57(4):537-546 (in Japanese).
- Nisimura J, Arai N, Tohmatsu J. Measurement of serum undercarboxylated osteocalcin by electro chemiluminescence immunoassay with the “Picolumi ucOC “kit. Jpn J Med Pharm Sci 2007;57(4):523–535 (in Japanese).
- Kaneki M, Hodges SJ, Hosoi T, Fujiwara S, Lyons A, Crean SJ, Ishida N, Nakagawa M, Takechi M, Sano Y, Mizuno Y, Hoshino S, Miyao M, Inoue S, Horiki K, Shiraki M, Ouchi Y, Orimo H. Japanese fermented soybean food as the major determinant of the large geographic difference in circulating levels of vitamin K2: possible implications for hip-fracture risk. Nutrition. 2001;4:315–21. CrossRef
- Tsugawa N, Shiraki M, Suhara Y, Kamao M, Ozaki R, Tanaka K, Okano T. Low plasma phylloquinone concentration is associated with high incidence of vertebral fracture in Japanese women. J Bone Miner Metab. 2008;26:79–85. CrossRef
- Serum 25-hydroxyvitamin D status in hip and spine-fracture patients in Japan
Journal of Orthopaedic Science
Volume 16, Issue 4 , pp 418-423
- Cover Date
- Print ISSN
- Online ISSN
- Springer Japan
- Additional Links
- Industry Sectors
- Author Affiliations
- 2. Department of Physical Therapy, Faculty of Medical Technology, Niigata University of Health and Welfare, Niigata, Japan
- 3. Division of Orthopedic Surgery, Department of Regenerative and Transplant Medicine, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Niigata, 951-8510, Japan
- 1. Committee on Osteoporosis of the Japan Orthopedic Association, Tokyo, Japan
- 5. School of Health Science, Faculty of Medicine, Tottori University, Yonago, Tottori, Japan
- 4. Department of Advanced Medicine, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan
- 6. Department of Orthopedic Surgery, Tamana Central Hospital, Kumamoto, Japan
- 7. Department of Orthopaedic Surgery, Sensory and Motor System Medicine, Surgical Sciences, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan