JBIC Journal of Biological Inorganic Chemistry

, Volume 6, Issue 4, pp 367–377

Syntheses and structures of M(L)(X)BPh4 complexes {M=Co(II), Zn(II); L=cis-1,3,5-tris[3-(2-furyl)prop-2-enylideneamino]cyclohexane, X=OAc, NO3}: structural models of the active site of carbonic anhydrase

  • Leroy Cronin
  • Simon P. Foxon
  • Paul J. Lusby
  • Paul H. Walton
Original Article

DOI: 10.1007/s007750100211

Cite this article as:
Cronin, L., Foxon, S.P., Lusby, P.J. et al. J. Biol. Inorg. Chem. (2001) 6: 367. doi:10.1007/s007750100211

Abstract

The metal coordination geometries in the structures of the zinc(II) and cobalt(II) complexes of the ligand cis-1,3,5-tris[3-(2-furyl)prop-2-enylideneamino]cyclohexane (fr-protach) and with the anions nitrate and acetate are structural models for the active site of carbonic anhydrase. The acetate structures show a striking structural correlation with the metal coordination environments in the known bicarbonate forms of the enzyme. Such structures provide a basis for understanding the marked effect of different metal substitution on the catalytic rate of the enzyme.

Keywords

Carbonic anhydrase Triaminocyclohexane Biomimicry Zinc Cobalt 

Copyright information

© SBIC 2001

Authors and Affiliations

  • Leroy Cronin
  • Simon P. Foxon
  • Paul J. Lusby
  • Paul H. Walton

There are no affiliations available