Abstract
Dinitrosyl iron complexes (DNICs) are physiological NO derivatives and account for many NO functions in biology. Polyfunctional dipeptide carnosine (beta-alanyl-l-histidine) is considered to be a very promising pharmacological agent. It was shown that in the system containing carnosine, iron ions and Angeli’s salt, a new type of DNICs bound with carnosine as ligand {(carnosine)2-Fe-(NO)2}, was formed. We studied how the carbonyl compound methylglyoxal influenced this process. Carnosine-bound DNICs appear to be one of the cell’s adaptation mechanisms when the amount of reactive carbonyl compounds increases at hyperglycemia. These complexes can also participate in signal and regulatory ways of NO and can act as protectors at oxidative and carbonyl stress conditions.
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Acknowledgements
The work was carried out with the financial support of the Russian Foundation for Basic Research (Grant 14-04-01710), the Russian Foundation for Humanities (Grant 15-36-01024), and the Ministry of Education and Science of the Russian Federation to Increase Competitiveness Program of MISiS (Agreement No. 02.A03.21.0004 of 27.08.2013).
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Shumaev, K.B., Kosmachevskaya, O.V., Nasybullina, E.I. et al. New dinitrosyl iron complexes bound with physiologically active dipeptide carnosine. J Biol Inorg Chem 22, 153–160 (2017). https://doi.org/10.1007/s00775-016-1418-z
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DOI: https://doi.org/10.1007/s00775-016-1418-z