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Control of redox reactivity of flavin and pterin coenzymes by metal ion coordination and hydrogen bonding

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Abstract

The electron-transfer activities of flavin and pterin coenzymes can be fine-tuned by coordination of metal ions, protonation and hydrogen bonding. Formation of hydrogen bonds with a hydrogen-bond receptor in metal–flavin complexes is made possible depending on the type of coordination bond that can leave the hydrogen-bonding sites. The electron-transfer catalytic functions of flavin and pterin coenzymes are described by showing a number of examples of both thermal and photochemical redox reactions, which proceed by controlling the electron-transfer reactivity of coenzymes with metal ion binding, protonation and hydrogen bonding.

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Acknowledgments

The authors gratefully acknowledge the contributions of their collaborators and coworkers mentioned in the references. The authors acknowledge continuous support of their study by Grants-in-Aid from the Ministry of Education, Culture, Sports, Science and Technology, Japan.

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  1. Department of Material and Life Science, Graduate School of Engineering, Osaka University, SORST, Japan Science and Technology Agency, 2-1 Yamada-oka, Suita, Osaka, 565-0871, Japan

    Shunichi Fukuzumi & Takahiko Kojima

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  1. Shunichi Fukuzumi
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  2. Takahiko Kojima
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Correspondence to Shunichi Fukuzumi.

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Fukuzumi, S., Kojima, T. Control of redox reactivity of flavin and pterin coenzymes by metal ion coordination and hydrogen bonding. J Biol Inorg Chem 13, 321–333 (2008). https://doi.org/10.1007/s00775-008-0343-1

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