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Dental treatments, tooth extractions, and osteonecrosis of the jaw in Japanese patients with rheumatoid arthritis: results from the IORRA cohort study

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Abstract

This study aimed to evaluate dental treatments, tooth extractions, and osteonecrosis of the jaw (ONJ) in Japanese patients with rheumatoid arthritis (RA). Patients with RA enrolled in our cohort completed self-administered questionnaires, which included questions regarding their dental treatments, tooth extractions by dentists during the past 6 months, and past history of ONJ. The history of ONJ was validated with the patients’ medical records. Logistic regression was used to determine the association of variables with dental treatments and tooth extractions during the past 6 months. Among 5695 Japanese patients with RA who responded to the questionnaires (mean age, 61.0 years; 85.6 % female), 2323 patients (40.8 %) and 378 patients (6.6 %) reported having had dental treatments and tooth extractions performed by a dentist within the past 6 months, respectively. In multivariate models, advanced age was significantly (P < 0.0001) associated with both dental treatments and tooth extractions during the prior 6-month period, and ever smoking was significantly (P = 0.023) correlated with tooth extractions during that time. Among patients who reported a history of ONJ, we confirmed five cases of ONJ with patient medical records. The prevalence of ONJ was 0.094 % among all RA patients and 0.26 % among female RA patients ≥65 years of age (n = 1888). Our data suggest that more than a few Japanese patients with RA have dental complications that require care by dentists, and that Japanese rheumatologists and dentists should cooperate to improve dental health in patients with RA.

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Acknowledgments

We thank Dr. Eisuke Inoue and all of the members of the Institute of Rheumatology, Tokyo Women’s Medical University, for the successful management of the IORRA cohort.

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Authors and Affiliations

  1. Institute of Rheumatology, Tokyo Women’s Medical University, 10-22 Kawada-cho, Shinjuku-ku, Tokyo, 162-0054, Japan

    Takefumi Furuya, Shigeki Momohara, Atsuo Taniguchi & Hisashi Yamanaka

  2. Department of Dental Anesthesiology, Okayama University Dental Hospital, 2-5-1 Shikata-cho, Okayama, 700-8525, Japan

    Shigeru Maeda

Authors
  1. Takefumi Furuya
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  2. Shigeru Maeda
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  3. Shigeki Momohara
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  4. Atsuo Taniguchi
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  5. Hisashi Yamanaka
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Corresponding author

Correspondence to Takefumi Furuya.

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Conflict of interest

S. Momohara has received honoraria for speaking and/or unrestricted research grants from AbbVie, Inc.; Asahi Kasei Pharma Corp.; Bristol-Myers Squibb Co.; Chugai Pharmaceutical Co.; Daiichi Sankyo Co., Ltd.; Eisai Co., Ltd.; Mitsubishi Tanabe Pharma Co.; Nakashima Medical Co., Ltd.; Santen Pharmaceutical Co., Ltd.; Taisho Toyama Pharmaceutical Co. Ltd.; and Takeda Pharmaceutical Co., Ltd. H. Y. has received research grants from Abbott, AbbVie, Asahikasei, Astellas, AstraZeneca, Bristol-Myers Squib, Chugai, Daiichi Sankyo, Eisai, GlaxoSmithKline, Janssen, Mitsubishi Tanabe, MSD, Nippon Kayaku, Pfizer, Santen, Taishotoyama, Takeda, and Teijin; has received consulting fees from Abbott, AbbVie, Astellas, AstraZeneca, Bristol-Myers Squib, Chugai, Daiichi Sankyo, Eisai, Mitsubishi Tanabe, Nippon Kayaku, Pfizer, Takeda, and Teijin; and has participated in speakers bureaus for Abbott, AbbVie, Astellas, Bristol-Myers Squib, Chugai, Eisai, Mitsubishi Tanabe, Pfizer, Takeda, and Teijin. The sponsors were not involved in the study design; collection, analysis, or interpretation of data; writing of the paper; or decision to submit for publication. The remaining authors have no conflict of interest to declare.

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Furuya, T., Maeda, S., Momohara, S. et al. Dental treatments, tooth extractions, and osteonecrosis of the jaw in Japanese patients with rheumatoid arthritis: results from the IORRA cohort study. J Bone Miner Metab 35, 344–350 (2017). https://doi.org/10.1007/s00774-016-0763-x

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  • DOI: https://doi.org/10.1007/s00774-016-0763-x

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