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Comparison of parathyroid hormone and strontium ranelate in combination with whole-body vibration in a rat model of osteoporosis

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Abstract

We investigated the combinatorial effects of whole-body vertical vibration (WBVV) with the primarily osteoanabolic parathyroid hormone (PTH) and the mainly antiresorptive strontium ranelate (SR) in a rat model of osteoporosis. Ovariectomies were performed on 76 three-month-old Sprague–Dawley rats (OVX, n = 76; NON-OVX, n = 12). After 8 weeks, the ovariectomized rats were divided into 6 groups. One group (OVX + PTH) received daily injections of PTH (40 µg/kg body weight/day) for 6 weeks. Another group (OVX + SR) was fed SR-supplemented chow (600 mg/kg body weight/day). Three groups (OVX + VIB, OVX + PTH + VIB, and OVX + SR + VIB) were treated with WBVV twice a day at 70 Hz for 15 min. Two groups (OVX + PTH + VIB, OVX + SR + VIB) were treated additionally with PTH and SR, respectively. The rats were killed at 14 weeks post-ovariectomy. The lumbar vertebrae and femora were removed for biomechanical and morphological assessment. PTH produced statistically significant improvements in biomechanical and structural properties, including bone mineral density (BMD) and trabecular bone quality. In contrast, SR treatment exerted mild effects, with significant effects in cortical thickness only. SR produced no significant improvement in biomechanical properties. WBVV as a single or an adjunctive therapy produced no significant improvements. In conclusion, vibration therapy administered as a single or dual treatment had no significant impact on bones affected by osteoporosis. PTH considerably improved bone quality in osteoporosis cases and is superior to treatment with SR.

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Acknowledgments

The present study was funded by the German Research Foundation (DFG SE 1966/5-1). The authors are grateful to R. Castro-Machguth and A. Witt for technical support.

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Authors and Affiliations

  1. Department of Trauma and Reconstructive Surgery, University of Goettingen, Robert Koch St. No. 40, 37075, Goettingen, Germany

    D. B. Hoffmann, S. Sehmisch, A. M. Hofmann, C. Eimer, M. Komrakova, D. Saul, K. M. Stürmer & M. Tezval

  2. Medical Institute of General Hygiene and Environmental Health, University of Goettingen, Kreuzbergring No. 57, 37075, Goettingen, Germany

    M. Wassmann

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  1. D. B. Hoffmann
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  2. S. Sehmisch
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Correspondence to D. B. Hoffmann.

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Hoffmann, D.B., Sehmisch, S., Hofmann, A.M. et al. Comparison of parathyroid hormone and strontium ranelate in combination with whole-body vibration in a rat model of osteoporosis. J Bone Miner Metab 35, 31–39 (2017). https://doi.org/10.1007/s00774-016-0736-0

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