Journal of Bone and Mineral Metabolism

, Volume 32, Issue 5, pp 533–538

Detective value of historical height loss and current height/knee height ratio for prevalent vertebral fracture in Japanese postmenopausal women

Original Article

DOI: 10.1007/s00774-013-0525-y

Cite this article as:
Yoh, K., Kuwabara, A. & Tanaka, K. J Bone Miner Metab (2014) 32: 533. doi:10.1007/s00774-013-0525-y

Abstract

Vertebral fracture (VFx) is associated with various co-morbidities and increased mortality. In this paper, we have studied the detective value of height loss for VFx using two indices; historical height loss (HHL) which is the difference between the maximal height, and the current height (CH), and CH/knee height (KH) ratio. One-hundred and fifty-one postmenopausal women visiting the outpatient clinic of orthopaedics were studied for their CH, self-reported maximal height, KH, and radiographically diagnosed VFx number(s). VFx was present in 41.1 % of the subjects. Multiple regression analyses revealed that the number of prevalent fractures was a significant predictor of HHL and CH/KH ratio. Receiver operator characteristic curve analysis has shown that for HHL, the area under the curve (AUC) with their 95 %CI in the parentheses was 0.84 (0.77, 0.90), 0.88 (0.83, 0.94), and 0.91 (0.86, 0.96) for ≥1, ≥2, and ≥3 fractures, respectively. For the presence of ≥1 VFx, the cut-off value was 4.0 cm (specificity 79 %; sensitivity 79 %). Regarding the CH/KH ratio, AUC was 0.73 (0.65, 0.82), 0.85 (0.78, 0.93), and 0.91 (0.86, 0.96) for ≥1, ≥2, and ≥3 fractures, respectively. For the presence of ≥1 VFx, the cut-off value was 3.3 (specificity 47 %; sensitivity 91 %). Both cut-off values for HHL and CH/KH ratio had high negative predictivity across the wide range of theoretical VFx prevalence. Thus, HHL and CH/KH were both good detectors of VFx. Our data would be the basis to determine the cut-off value for the screening or case finding of subjects with VFx.

Keywords

Historical height lossKnee heightVertebral fractureJapanese postmenopausal women

Copyright information

© The Japanese Society for Bone and Mineral Research and Springer Japan 2013

Authors and Affiliations

  1. 1.Sasayama Medical CenterHyogo Medical CollegeSasayamaJapan
  2. 2.Department of Health and NutritionOsaka Shoin Women’s UniversityHigashiosakaJapan
  3. 3.Department of Food and NutritionKyoto Women’s UniversityKyotoJapan