Original Article

Journal of Bone and Mineral Metabolism

, Volume 31, Issue 5, pp 579-584

Serum sclerostin levels in healthy men over 50 years of age

  • Harjit Pal BhattoaAffiliated withDepartment of Laboratory Medicine, Medical and Health Science Center, University of DebrecenRegional Osteoporosis Center, Department of Obstetrics and Gynecology, Medical and Health Science Center, University of Debrecen Email author 
  • , John WamwakiAffiliated withDepartment of Laboratory Medicine, Medical and Health Science Center, University of Debrecen
  • , Edit KalinaAffiliated withDepartment of Laboratory Medicine, Medical and Health Science Center, University of Debrecen
  • , Roza FoldesiAffiliated withDepartment of Laboratory Medicine, Medical and Health Science Center, University of Debrecen
  • , Adam BaloghAffiliated withRegional Osteoporosis Center, Department of Obstetrics and Gynecology, Medical and Health Science Center, University of Debrecen
  • , Peter Antal-SzalmasAffiliated withDepartment of Laboratory Medicine, Medical and Health Science Center, University of Debrecen

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access

Abstract

The aim of this study is to evaluate the relationship of serum sclerostin levels with age, cystatin C, bone mineral density (BMD) and biochemical markers of bone turnover in healthy Hungarian men >50 years of age. We determined serum levels of sclerostin and examined its relationship to age, cystatin C, osteocalcin, C-terminal telopeptides of type-I collagen, procollagen type 1 amino-terminal propeptide, 25-hydroxyvitamin D, parathyroid hormone, and L1–L4 (LS) and femur neck (FN) BMD data available from 194 randomly selected ambulatory men belonging to the HunMen cohort. In the study population as a whole [n = 194; age (median, range) 59 (51–81) years], statistically significant correlation was found between sclerostin and age (r = 0.211; p = 0.003), cystatin C (r = 0.246; p = 0.001), FN BMD (r = 0.147; p = 0.041) and LS BMD (r = 0.169; p = 0.019). Compared to middle-aged men (age ≤59 years, n = 98), elderly men (age >59 years, n = 96) had significantly higher serum sclerostin levels (67.8 ± 15.9 vs 63.5 ± 14 pmol/L; p = 0.047). Among men with normal (T score >−1.0) FN BMD, the elderly had significantly higher serum sclerostin levels compared to the middle-aged men (70.4 ± 17 vs 63.9 ± 11.5 pmol/L; p = 0.019). Furthermore, among the elderly men cystatin C was the only significant predictor of serum sclerostin levels (standardized regression coefficient (β) = 0.487; p < 0.001). In the studied healthy elderly cohort, this study reports a significant increase in sclerostin levels with increasing age and deteriorating kidney function as determined by plasma cystatin C levels.

Keywords

Sclerostin Cystatin c Markers of bone turnover Bone mineral density Men