Journal of Bone and Mineral Metabolism

, Volume 28, Issue 6, pp 682–689

Densitometric and geometric measurement of the proximal femur in elderly women with and without osteoporotic vertebral fractures by volumetric quantitative multi-slice CT

Authors

    • Medical Image Institute of Tianjin
    • Department of RadiologyFirst Central Hospital of Tianjin Medical University
  • Ji Qi
    • Medical Image Institute of Tianjin
    • Department of RadiologyFirst Central Hospital of Tianjin Medical University
  • Ying Lu
    • Department of Health Research and PolicyStanford University
  • Jing Lan
    • Department of RadiologyTianjin Medical University
  • Jin-chao Yu
    • Department of RadiologyFirst Central Hospital of Tianjin Medical University
  • Lian-qing Wen
    • Department of RadiologyFirst Central Hospital of Tianjin Medical University
    • Department of RadiologyNorthwestern University
Original Article

DOI: 10.1007/s00774-010-0174-3

Cite this article as:
Wu, S., Qi, J., Lu, Y. et al. J Bone Miner Metab (2010) 28: 682. doi:10.1007/s00774-010-0174-3

Abstract

There is a lack of research on volumetric multi-slice CT (MSCT) application in hip densitometric assessment and geometric measures in elderly women with osteoporotic vertebral fractures. A total of 237 elderly women were divided into three groups based on BMD values of the lumbar spine (AP-SPINE) and/or the femoral neck (NECK) by dual energy X-ray absorptiometry (DXA): osteoporosis with (OP_FX, 53 cases) or without vertebral fracture (OP_NONFX, 94 cases), or normal BMD (CONTROL, 90 cases). Volumetric BMD of trabecular bone (TRAB), integral bone (INTGL) and cortical bone (CORT) with neck axis length (NAL) and minimum cross-section area (mCSA) measures of the left femoral neck were calculated, respectively, by using OsteoCAD software based on MSCT scans of the abdominal-pelvic region of all participants, then the index of femoral neck strength (FNSI) was estimated. The values of TRAB, CORT and INTGL of OP_FX were significantly lower than those of OP_NONFX, with the decrease in 6.8–21.8%, as well as being lower than those in CONTROL, whereas no significant differences in the values of AP-SPINE and NECK were found between OP_FX and OP_NONFX. No significant difference of the value of mCSA was found among these three groups. The NAL value of OP_NONFX was larger than that of CONTROL. FNSI of femoral neck in OP_FX (0.42 ± 0.15 g2/cm4) was significantly lower than OP_NONFX (0.50 ± 0.14 g2/cm4) (p < 0.05). vQCT measurement seemed to be more effective than DXA in evaluating hip densitometric changes and discriminating osteoporotic elderly subjects with fractured vertebrae from the non-fractured in a group of Chinese women.

Keywords

Osteoporosis Bone mineral density (BMD) Volumetric QCT Hip fracture Elderly women

Copyright information

© The Japanese Society for Bone and Mineral Research and Springer 2010