Journal of Bone and Mineral Metabolism

, Volume 28, Issue 6, pp 682–689

Densitometric and geometric measurement of the proximal femur in elderly women with and without osteoporotic vertebral fractures by volumetric quantitative multi-slice CT

Original Article

DOI: 10.1007/s00774-010-0174-3

Cite this article as:
Wu, S., Qi, J., Lu, Y. et al. J Bone Miner Metab (2010) 28: 682. doi:10.1007/s00774-010-0174-3
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Abstract

There is a lack of research on volumetric multi-slice CT (MSCT) application in hip densitometric assessment and geometric measures in elderly women with osteoporotic vertebral fractures. A total of 237 elderly women were divided into three groups based on BMD values of the lumbar spine (AP-SPINE) and/or the femoral neck (NECK) by dual energy X-ray absorptiometry (DXA): osteoporosis with (OP_FX, 53 cases) or without vertebral fracture (OP_NONFX, 94 cases), or normal BMD (CONTROL, 90 cases). Volumetric BMD of trabecular bone (TRAB), integral bone (INTGL) and cortical bone (CORT) with neck axis length (NAL) and minimum cross-section area (mCSA) measures of the left femoral neck were calculated, respectively, by using OsteoCAD software based on MSCT scans of the abdominal-pelvic region of all participants, then the index of femoral neck strength (FNSI) was estimated. The values of TRAB, CORT and INTGL of OP_FX were significantly lower than those of OP_NONFX, with the decrease in 6.8–21.8%, as well as being lower than those in CONTROL, whereas no significant differences in the values of AP-SPINE and NECK were found between OP_FX and OP_NONFX. No significant difference of the value of mCSA was found among these three groups. The NAL value of OP_NONFX was larger than that of CONTROL. FNSI of femoral neck in OP_FX (0.42 ± 0.15 g2/cm4) was significantly lower than OP_NONFX (0.50 ± 0.14 g2/cm4) (p < 0.05). vQCT measurement seemed to be more effective than DXA in evaluating hip densitometric changes and discriminating osteoporotic elderly subjects with fractured vertebrae from the non-fractured in a group of Chinese women.

Keywords

OsteoporosisBone mineral density (BMD)Volumetric QCTHip fractureElderly women

Copyright information

© The Japanese Society for Bone and Mineral Research and Springer 2010

Authors and Affiliations

  1. 1.Medical Image Institute of TianjinTianjinPeople’s Republic of China
  2. 2.Department of RadiologyFirst Central Hospital of Tianjin Medical UniversityTianjinPeople’s Republic of China
  3. 3.Department of Health Research and PolicyStanford UniversityStanfordUSA
  4. 4.Department of RadiologyTianjin Medical UniversityTianjinPeople’s Republic of China
  5. 5.Department of RadiologyNorthwestern UniversityChicagoUSA