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Bisphosphonate-related osteonecrosis of the jaw: position paper from the Allied Task Force Committee of Japanese Society for Bone and Mineral Research, Japan Osteoporosis Society, Japanese Society of Periodontology, Japanese Society for Oral and Maxillofacial Radiology, and Japanese Society of Oral and Maxillofacial Surgeons

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Abstract

Bisphosphonates (BPs) have been widely, efficiently, and safely used for the treatment of osteoporosis, malignant hypercalcemia, bone metastasis of solid cancers, and multiple myeloma bone diseases. Accumulating recent reports describe that surgical dental treatments in patients with cancer or osteoporosis who have been receiving intravenous or oral BPs are associated with osteonecrosis of the jaw (bisphosphonate-related osteonecrosis of the jaw, BRONJ). The accurate incidence, clinical backgrounds, and pathogenesis of BRONJ have been unclear and appropriate approaches for prevention and treatment have not been established to date. To address the current situation of BRONJ in Japan, the “Allied Task Force Committee of Bisphosphonate-Related Osteonecrosis of the Jaw,” consisting of physicians specializing in bone biology, orthopedic surgery, rheumatology, obstetrics/gynecology, and medical oncology and dentists specializing in oral surgery, periodontology, dental radiology, and oral pathology, was organized. The committee attempted to propose a standard position paper for the treatment of BRONJ. The committee expects that this proposal will provide objective and correct scientific information on BRONJ and will serve as a reference for conducting dental procedures for patients receiving BPs and in designing prevention and treatment of BRONJ. However, because this position paper is not based on direct clinical evidence, it should be used as a reference, and a decision on treatment in each case should be made after an extensive discussion among physicians, dentists/oral surgeons, and the patients.

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Authors and Affiliations

  1. Department of Biochemistry, Osaka University Graduate School of Dentistry, 1-8 Yamadaoka, Suita, Osaka, 565-0871, Japan

    Toshiyuki Yoneda

  2. School of Health Science, Faculty of Medicine, Tottori University Hospital, Yonago, Japan

    Hiroshi Hagino

  3. Internal Medicine 1, Shimane University Faculty of Medicine, Izumo, Japan

    Toshitsugu Sugimoto

  4. Department of Obstetrics and Gynecology, Tokyo Women’s Medical University, Tokyo, Japan

    Hiroaki Ohta

  5. Division of Clinical Chemotherapy, Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Tokyo, Japan

    Shunji Takahashi

  6. Department of Orthopaedic Surgery and Rheumatology, Nara Hospital, Kinki University School of Medicine, Nara, Japan

    Satoshi Soen

  7. Department of Oral and Maxillofacial Radiology, Matsumoto Dental University, Shiojiri, Japan

    Akira Taguchi

  8. Department of Oral Pathology, Osaka University Graduate School of Dentistry, Osaka, Japan

    Satoru Toyosawa

  9. Department of Periodontology and Endodontology, Institute of Health Bioscience, The University of Tokushima Graduate School, Tokushima, Japan

    Toshihiko Nagata

  10. Department of Oral and Maxillofacial Surgery, Hyogo College of Medicine, Hyogo, Japan

    Masahiro Urade

Authors
  1. Toshiyuki Yoneda
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  2. Hiroshi Hagino
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  3. Toshitsugu Sugimoto
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  4. Hiroaki Ohta
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  5. Shunji Takahashi
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  6. Satoshi Soen
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  7. Akira Taguchi
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  8. Satoru Toyosawa
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  9. Toshihiko Nagata
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  10. Masahiro Urade
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Corresponding author

Correspondence to Toshiyuki Yoneda.

Additional information

Authors belonging to the Review Committee of The Bisphosphonate-Related Osteonecrosis of the Jaw are given in the Appendix.

Appendix

Appendix

Toshiyuki Yoneda, Hiroshi Hagino, Toshitsugu Sugimoto, Shunji Takahashi: The Japanese Society for Bone and Mineral Research; Hiroaki Ohta, Satoshi Soen, Satoru Toyosawa: Japan Osteoporosis Society; Akira Taguchi: The Japanese Society for Oral and Maxillofacial Radiology; Toshihiko Nagata: The Japanese Society of Periodontology; Masahiro Urade: The Japanese Society of Oral and Maxillofacial Surgeons.

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Yoneda, T., Hagino, H., Sugimoto, T. et al. Bisphosphonate-related osteonecrosis of the jaw: position paper from the Allied Task Force Committee of Japanese Society for Bone and Mineral Research, Japan Osteoporosis Society, Japanese Society of Periodontology, Japanese Society for Oral and Maxillofacial Radiology, and Japanese Society of Oral and Maxillofacial Surgeons. J Bone Miner Metab 28, 365–383 (2010). https://doi.org/10.1007/s00774-010-0162-7

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  • DOI: https://doi.org/10.1007/s00774-010-0162-7

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