Abstract
Jump exercise in rats creates high-impact loading on lower limbs and results in the promotion of osteogenesis. Although we clarifi ed that a few loadings per day could increase bone mass and strength within 8 weeks, we did not observe an osteogenic response at the onset of the training period. The purpose of this study was to clarify whether the bone formation rate measured by the double-label immunofluorescence method increases with a few loadings for a short period. Forty female Wistar rats, 10 weeks old, were divided into a control group and three exercise groups: the 10 jumps/day (10 J) group, 40 jumps/day (40 J) group, and 100 jumps/day (100 J) group. The exercise groups were trained on days 1, 3, and 5, the fluorescent labels were injected on days 5 and 12, and the experiment ended on day 16. The bone formation rates were greater in all exercise groups compared with the control group and were significantly greater in the 40 J and 100 J groups than in the 10 J group. These data show that only 10 repetitions/day loading promotes the osteogenic response within a short period from the onset of the training.
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Nagasawa, S., Honda, A., Sogo, N. et al. Effects of low-repetition jump exercise on osteogenic response in rats. J Bone Miner Metab 26, 226–230 (2008). https://doi.org/10.1007/s00774-007-0812-6
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DOI: https://doi.org/10.1007/s00774-007-0812-6