Abstract
Changes in mental health symptoms throughout pregnancy and postpartum may impact a woman’s experience and adjustment during an important time. However, few studies have investigated these changes throughout the perinatal period, particularly changes in posttraumatic stress disorder (PTSD) symptoms. The purpose of this study was to examine longitudinal changes in PTSD, depression, and anxiety symptomatology during pregnancy and postpartum. Pregnant women of ethnically diverse backgrounds receiving services for prenatal care at an outpatient obstetric-gynecology clinic or private physicians’ office were assessed by interview on symptoms of PTSD, depression, anxiety, and general stress up to four times, including their first, second, and third trimester, and postpartum visits. Overall, during pregnancy there was a declining trend of PTSD symptoms. For anxiety, there was no overall significant change over time; however, anxiety symptoms were individually variable in the rate of change. For both depression and general stress symptoms, there was a declining trend, which was also variable in the individual rate of change among women during their pregnancy. Visual and post hoc analyses also suggest a possible peak in PTSD symptoms in the weeks prior to delivery. While most mental health symptoms may generally decrease during pregnancy, given the individual variability among women in the rate of change in symptoms, screening and monitoring of symptom fluctuations throughout the course of pregnancy may be needed. Further studies are needed to examine potential spiking of symptoms in the perinatal period.
Similar content being viewed by others
References
Alcorn KL, O’Donovan A, Patrick JC, Creedy D, Devilly GJ (2010) A prospective longitudinal study of the prevalence of post-traumatic stress disorder resulting from childbirth events. Psychol Med 40(11):1849–1859. doi:10.1017/s0033291709992224
Alder J, Fink N, Bitzer J, Hosli I, Holzgreve W (2007) Depression and anxiety during pregnancy: a risk factor for obstetric, fetal and neonatal outcome? A critical review of the literature. J Matern Fetal Neonatal Med 20(3):189–209. doi:10.1080/14767050701209560
American Psychiatric Association (1994) Diagnostic and Statistical Manual of Mental Disorders (DSM-IV), 4th edn. American Psychiatric Association, Washington, D.C
Apter G, Devouche E, Gratier M (2011) Perinatal mental health. J Nerv Ment Dis 199(8):575–577. doi:10.1097/NMD.0b013e318225f2f4
Ayers S, Eagle A, Waring H (2006) The effects of childbirth-related post-traumatic stress disorder on women and their relationships: a qualitative study. Psychol Health Med 11(4):389–398. doi:10.1080/13548500600708409
Ayers S, Harris R, Sawyer A, Parfitt Y, Ford E (2009) Posttraumatic stress disorder after childbirth: analysis of symptom presentation and sampling. J Affective Disord 119(1–3):200–204. doi:10.1016/j.jad.2009.02.029
Azar R, Singer S (2012) Maternal prenatal state anxiety symptoms and birth weight: a pilot study. Cent Eur J Med 7(6):747–752. doi:10.2478/s11536-012-0078-9
Beck CT, Gable RK, Sakala C, Declercq ER (2011) Posttraumatic stress disorder in new mothers: results from a two-stage U.S. national survey. Birth 38(3):216–227. doi:10.1111/j.1523-536X.2011.00475.x
Bennett HA, Einarson A, Taddio A, Koren G, Einarson TR (2004) Prevalence of depression during pregnancy: systematic review. Gynecology 103(4):698–709. doi:10.1097/01.AOG.0000116689.75396.5f
Blanchard EB, Jones-Alexander J, Buckley TC, Forneris CA (1996) Psychometric properties of the PTSD checklist (PCL). Behav Res Ther 34(8):669–673. doi:10.1016/0005-7967(96)00033-2
Bliese PD, Wright KM, Adler AB, Cabrera O, Castro CA, Hoge CW (2008) Validating the primary care posttraumatic stress disorder screen and the posttraumatic stress disorder checklist with soldiers returning from combat. J Consult Clin Psychol 76(2):272–281. doi:10.1037/0022-006x.76.2.272
Born L, Soares CN, Phillips SD, Jung M, Steiner M (2006) Women and reproductive-related trauma. Ann N Y Acad Sci 1071:491–494. doi:10.1196/annals.1364.049
Brand SR, Brennan PA (2009) Impact of antenatal and postpartum maternal mental illness: how are the children? Clin Obstet Gynecol 52(3):441–455. doi:10.1097/GRF.0b013e3181b52930
Breslau N, Davis GC, Peterson EL, Schultz LR (2000) A second look at comorbidity in victims of trauma: the posttraumatic stress disorder–major depression connection. Biol Psychiatry 48(9):902–909. doi:10.1016/S0006-3223(00)00933-1
Breslau N, Lucia VC, Davis GC (2004) Partial PTSD versus full PTSD: an empirical examination of associated impairment. Psychol Med 34(7):1205–1214. doi:10.1017/S0033291704002594
Brooks J, Nathan E, Speelman C, Swalm D, Jacques A, Doherty D (2009) Tailoring screening protocols for perinatal depression: prevalence of high risk across obstetric services in Western Australia. Arch Womens Ment Health 12(2):105–112. doi:10.1007/s00737-009-0048-7
Bruce SE, Weisberg RB, Dolan RT, Machan JT, Kessler RC, Manchester G, Culpepper L, Keller MB (2001) Trauma and posttraumatic stress disorder in primary care patients. Prim Care Companion J Clin Psychiatry 3(5):211–217
Cerulli CC, Talbot NLNL, Tang WW, Chaudron LHLH (2011) Co-occurring intimate partner violence and mental health diagnoses in perinatal women. CORD Conf Proc 20(12):1797–1803
Class QA, Lichtenstein P, Langstrom N, D’Onofrio BM (2011) Timing of prenatal maternal exposure to severe life events and adverse pregnancy outcomes: a population study of 2.6 million pregnancies. Psychosom Med 73(3):234–241. doi:10.1097/PSY.0b013e31820a62ce
Cohen S, Kamarck T, Mermelstein R (1983) A global measure of perceived stress. J Health Soc Behav 24(4):385–396. doi:10.2307/2136404
Dennis MF, Flood AM, Reynolds V, Araujo G, Clancy CP, Barefoot JC, Beckham JC (2009) Evaluation of lifetime trauma exposure and physical health in women with posttraumatic stress disorder or major depressive disorder. Violence Against Women 15(5):618–627. doi:10.1177/1077801209331410
Dunkel Schetter C, Tanner L (2012) Anxiety, depression and stress in pregnancy: implications for mothers, children, research, and practice. Curr Opin Psychiatry 25(2):141–148. doi:10.1097/YCO.0b013e3283503680
Evans J, Heron J, Francomb H, Oke S, Golding J (2001) Cohort study of depressed mood during pregnancy and after childbirth. BMJ 323(7307):257–260. doi:10.1136/bmj.323.7307.257
Federenko IS, Wadhwa PD (2004) Women’s mental health during pregnancy influences fetal and infant developmental and health outcomes. CNS Spectr 9(3):198–206
Forray A, Mayes LC, Magriples U, Epperson CN (2009) Prevalence of post-traumatic stress disorder in pregnant women with prior pregnancy complications. J Matern Fetal Neonatal Med 22(6):522–527. doi:10.1080/14767050902801686
Freedy JR, Steenkamp MM, Magruder KM, Yeager DE, Zoller JS, Hueston WJ, Carek PJ (2010) Post-traumatic stress disorder screening test performance in civilian primary care. Fam Pract 27(6):615–624. doi:10.1093/fampra/cmq049
Gavin NI, Gaynes BN, Lohr KN, Meltzer-Brody S, Gartlehner G, Swinson T (2005) Perinatal depression: a systematic review of prevalence and Incidence. Obstet Gynecol 106 (5, Part 1):1071–1083. doi:1010.1097/1001.AOG.0000183597.0000131630.db
Glynn LM, Schetter CD, Hobel CJ, Sandman CA (2008) Pattern of perceived stress and anxiety in pregnancy predicts preterm birth. Health Psychol 27(1):43–51. doi:10.1037/0278-6133.27.1.43
Goebert D, Morland L, Frattarelli L, Onoye J, Matsu C (2007) Mental health during pregnancy: a study comparing Asian, Caucasian and native Hawaiian women. Matern Child Health J 11(3):249–255. doi:10.1007/s10995-006-0165-0
Heron J, O’Connor TG, Evans J, Golding J, Glover V (2004) The course of anxiety and depression through pregnancy and the postpartum in a community sample. J Affect Disord 80(1):65–73. doi:10.1016/j.jad.2003.08.004
Homish GG, Cornelius JR, Richardson GA, Day NL (2004) Antenatal risk factors associated with postpartum comorbid alcohol use and depressive symptomatology. Alcohol Clin Exp Res 28(8):1242–1248
Hosseini SM, Biglan MW, Larkby C, Brooks MM, Gorin MB, Day NL (2009) Trait anxiety in pregnant women predicts offspring birth outcomes. Paediatr Perinat Epidemiol 23(6):557–566. doi:10.1111/j.1365-3016.2009.01065.x
Hung T-H, Lo L-M, Chiu T-H, Li M-J, Yeh Y-L, Chen S-F, Hsieh T-T (2010) A longitudinal study of oxidative stress and antioxidant status in women with uncomplicated pregnancies throughout gestation. Reprod Sci 17(4):401–409. doi:10.1177/1933719109359704
Kessler RC, Berglund P, Demler O, Jin R, Merikangas KR, Walters EE (2005) Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the national comorbidity survey replication. Arch Gen Psychiatry 62(6):593–602. doi:10.1001/archpsyc.62.6.593
Koubovec D, Geerts L, Odendaal HJ, Stein DJ, Vythilingum B (2005) Effects of psychologic stress on fetal development and pregnancy outcome. Curr Psychiatry Rep 7(4):274–280
Kubany ES, Haynes SN, Leisen MB, Owens JA, Kaplan AS, Watson SB, Burns K (2000) Development and preliminary validation of a brief broad-spectrum measure of trauma exposure: the traumatic life events questionnaire. Psychol Assess 12(2):210–224. doi:10.1037/1040-3590.8.4.428
Littleton HL, Breitkopf CR, Berenson AB (2007) Correlates of anxiety symptoms during pregnancy and association with perinatal outcomes: a meta-analysis. Am J Obstet Gynecol 196(5):424–432. doi:10.1016/j.ajog.2007.03.042
Loveland Cook CA, Flick LH, Homan SM, Campbell C, McSweeney M, Gallagher ME (2004) Posttraumatic stress disorder in pregnancy: prevalence, risk factors, and treatment. Obstet Gynecol 103(4):710–717. doi:10.1097/01.AOG.0000119222.40241.fb
Maggioni C, Margola D, Filippi F (2006) PTSD, risk factors, and expectations among women having a baby: a two-wave longitudinal study. J Psychosom Obstet Gynaecol 27(2):81–90. doi:10.1080/01674820600712875
Manne SL, Du Hamel K, Gallelli K, Sorgen K, Redd WH (1998) Posttraumatic stress disorder among mothers of pediatric cancer survivors: diagnosis, comorbidity, and utility of the PTSD checklist as a screening instrument. J Pediatr Psychol 23(6):357–366
Marcus SM, Flynn HA, Blow FC, Barry KL (2003) Depressive symptoms among pregnant women screened in obstetrics settings. J Womens Health (Larchmt) 12(4):373–380. doi:10.1089/154099903765448880
Mezey G, Bacchus L, Bewley S, White S (2005) Domestic violence, lifetime trauma and psychological health of childbearing women. BJOG 112(2):197–204. doi:10.1111/j.1471-0528.2004.00307.x
Monk C (2001) Stress and mood disorders during pregnancy: implications for child development. Psychiatr Q 72(4):347–357. doi:10.1023/A:1010393316106
Morland LA, Goebert DA, Onoye JM, Frattarelli L, Derauf C, Herbst M, Matsu C, Friedman M (2007) Posttraumatic stress disorder and pregnancy health: preliminary update and implications. Psychosomatics 48(4):304–308. doi:10.1176/appi.psy.48.4.304
Mosack V, Shore ER (2006) Screening for depression among pregnant and postpartum women. J Community Health Nurs 23(1):37–47. doi:10.1207/s15327655jchn2301_4
Onoye JM, Goebert D, Morland L, Matsu C, Wright T (2009) PTSD and postpartum mental health in a sample of Caucasian, Asian, and Pacific Islander women. Arch Womens Ment Health 12(6):393–400. doi:10.1007/s00737-009-0087-0
Radloff L (1977) The CES-D scale: a self-report depression scale for research in the general population. Appl Psychol Meas 1(3):385–401. doi:10.1177/014662167700100306
Resnick HS, Kilpatrick DG, Dansky BS, Saunders BE, Best CL (1993) Prevalence of civilian trauma and posttraumatic stress disorder in a representative national sample of women. J Consult Clin Psychol 61(6):984–991. doi:10.1037/0022-006X.61.6.984
Rodríguez MA, Valentine J, Ahmed SR, Eisenman DP, Sumner LA, Heilemann MV, Liu H (2010) Intimate partner violence and maternal depression during the perinatal period: a longitudinal investigation of Latinas. Violence Against Women 16(5):543–559. doi:10.1177/1077801210366959
Rogal SS, Poschman K, Belanger K, Howell HB, Smith MV, Medina J, Yonkers KA (2007) Effects of posttraumatic stress disorder on pregnancy outcomes. J Affect Disord 102(1–3):137–143. doi:10.1016/j.jad.2007.01.003
Rondo PH, Vaz AJ, Moraes F, Tomkins A (2004) The relationship between salivary cortisol concentrations and anxiety in adolescent and non-adolescent pregnant women. Braz J Med Biol Res 37(9):1403–1409
Rosen D, Seng JS, Tolman RM, Mallinger G (2007) Intimate partner violence, depression, and posttraumatic stress disorder as additional predictors of low birth weight infants among low-income mothers. J Interpers Violence 22(10):1305–1314. doi:10.1177/0886260507304551
Ross LE, McLean LM (2006) Anxiety disorders during pregnancy and the postpartum period: a systematic review. J Clin Psychiatry 67(8):1285–1298
Rothenberger SE, Moehler E, Reck C, Resch F (2011) Prenatal stress: course and interrelation of emotional and physiological stress measures. Psychopathology 44(1):60–67. doi:10.1159/000319309
Seng JS (2002) A conceptual framework for research on lifetime violence, posttraumatic stress, and childbearing. J Midwifery Womens Health 47(5):337–346
Seng JS, Oakley DJ, Sampselle CM, Killion C, Graham-Bermann S, Liberzon I (2001) Posttraumatic stress disorder and pregnancy complications. Obstet Gynecol 97(1):17–22
Seng JS, Low LK, Sperlich M, Ronis DL, Liberzon I (2009) Prevalence, trauma history, and risk for posttraumatic stress disorder among nulliparous women in maternity care. Obstet Gynecol 114(4):839–847. doi:10.1097/AOG.0b013e3181b8f8a2
Seng JS, Rauch SA, Resnick H, Reed CD, King A, Low LK, McPherson M, Muzik M, Abelson J, Liberzon I (2010) Exploring posttraumatic stress disorder symptom profile among pregnant women. J Psychosom Obstet Gynaecol 31(3):176–187. doi:10.3109/0167482x.2010.486453
Seng JS, Kohn-Wood LP, McPherson MD, Sperlich M (2011a) Disparity in posttraumatic stress disorder diagnosis among African American pregnant women. Arch Womens Ment Health 14(4):295–306. doi:10.1007/s00737-011-0218-2
Seng JS, Low LK, Sperlich M, Ronis DL, Liberzon I (2011b) Post-traumatic stress disorder, child abuse history, birthweight and gestational age: a prospective cohort study. BJOG 118(11):1329–1339. doi:10.1111/j.1471-0528.2011.03071.x
Smith MV, Rosenheck RA, Cavaleri MA, Howell HB, Poschman K, Yonkers KA (2004) Screening for and detection of depression, panic disorder, and PTSD in public-sector obstetric clinics. Psychiatr Serv 55(4):407–414. doi:10.1176/appi.ps.55.4.407
Smith MV, Poschman K, Cavaleri MA, Howell HB, Yonkers KA (2006) Symptoms of posttraumatic stress disorder in a community sample of low-income pregnant women. Am J Psychiatry 163(5):881–884. doi:10.1176/appi.ajp.163.5.881
Soderquist J, Wijma B, Wijma K (2006) The longitudinal course of post-traumatic stress after childbirth. J Psychosom Obstet Gynaecol 27(2):113–119
Spielberger CD, Gorsuch RL, Lushene R, Vagg PR, Jacobs GA (1983) Manual for the State-Trait Anxiety Inventory. Consulting Psychologists, Palo Alto
Stein MB, Walker JR, Hazen AL, Forde DR (1997) Full and partial posttraumatic stress disorder: findings from a community survey. Am J Psychiatry 154(8):1114–1119
Tollenaar MS, Beijers R, Jansen J, Riksen-Walraven JM, de Weerth C (2010) Maternal prenatal stress and cortisol reactivity to stressors in human infants. Stress 13(6):491–497. doi:10.3109/10253890.2010.499485
van Bussel J, Spitz B, Demyttenaere K (2009) Depressive symptomatology in pregnant and postpartum women. An exploratory study of the role of maternal antenatal orientations. Arch Womens Ment Health 12(3):155–166. doi:10.1007/s00737-009-0061-x
Van den Bergh BR, Mulder EJ, Mennes M, Glover V (2005) Antenatal maternal anxiety and stress and the neurobehavioural development of the fetus and child: links and possible mechanisms. A review. Neurosci Biobehav Rev 29(2):237–258. doi:10.1016/j.neubiorev.2004.10.007
Vesga-Lopez O, Blanco C, Keyes K, Olfson M, Grant BF, Hasin DS (2008) Psychiatric disorders in pregnant and postpartum women in the United States. Arch Gen Psychiatry 65(7):805–815. doi:10.1001/archpsyc.65.7.805
Wadhwa PD, Sandman CA, Garite TJ (2001) The neurobiology of stress in human pregnancy: implications for prematurity and development of the fetal central nervous system. Prog Brain Res 133:131–142
Weathers FW, Litz BT, Huska JA, Keane TM (1994) PTSD Checklist—Civilian version. National Center for PTSD, Behavioral Science Division, Boston
Wenzel A, Haugen EN, Jackson LC, Brendle JR (2005) Anxiety symptoms and disorders at eight weeks postpartum. J Anxiety Disord 19(3):295–311. doi:10.1016/j.janxdis.2004.04.001
Yampolsky L, Lev-Wiesel R, Ben-Zion IZ (2010) Child sexual abuse: is it a risk factor for pregnancy? J Adv Nurs 66(9):2025–2037. doi:10.1111/j.1365-2648.2010.05387.x
Yarvis JS, Schiess L (2008) Subthreshold posttraumatic stress disorder (PTSD) as a predictor of depression, alcohol use, and health problems in veterans. J Work Behav Health 23(4):395–424
Yim IS, Glynn LM, Dunkel Schetter C, Hobel CJ, Chicz-DeMet A, Sandman CA (2009) Risk of postpartum depressive symptoms with elevated corticotropin-releasing hormone in human pregnancy. Arch Gen Psychiatry 66(2):162–169. doi:10.1001/archgenpsychiatry.2008.533
Zaers S, Waschke M, Ehlert U (2008) Depressive symptoms and symptoms of post-traumatic stress disorder in women after childbirth. J Psychosom Obstet Gynaecol 29(1):61–71. doi:10.1080/01674820701804324
Zelkowitz P, Saucier JF, Wang T, Katofsky L, Valenzuela M, Westreich R (2008) Stability and change in depressive symptoms from pregnancy to two months postpartum in childbearing immigrant women. Arch Womens Ment Health 11(1):1–11. doi:10.1007/s00737-008-0219-y
Acknowledgments and declarations
This research was supported, in part, by a Research Centers in Minority Institutions Award (P20 RR11091) from the National Center for Research Resources (NCRR), National Institutes of Health. Dissemination was supported in part by a National Institute on Alcohol Abuse and Alcoholism (NIAAA) and National Center on Minority Health and Disparities (NCMHD) Award (5U01AA014289-03) and The Queen’s Medical Center (QMC). Drs. Onoye and Goebert are faculty of the University of Hawai‘i (UH) John A. Burns School of Medicine as well as Senior Scientists at QMC. Dr. Matsu is also affiliated with QMC. The contents of this paper are solely the responsibility of the authors and do not represent the official views of NIAAA, NCMHD, NCRR, or QMC. The investigators thank the women and staff from the clinics that participated in and supported the study.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Onoye, J.M., Shafer, L.A., Goebert, D.A. et al. Changes in PTSD symptomatology and mental health during pregnancy and postpartum. Arch Womens Ment Health 16, 453–463 (2013). https://doi.org/10.1007/s00737-013-0365-8
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00737-013-0365-8