Short Communication

Archives of Women's Mental Health

, Volume 16, Issue 1, pp 79-81

Comorbid bipolar disorder and premenstrual dysphoric disorder: real patients, unanswered questions

  • Benicio N. FreyAffiliated withWomen’s Health Concerns Clinic, St. Joseph’s Healthcare Hamilton, McMaster UniversityMood Disorders Program, Department of Psychiatry and Behavioural Neurosciences, McMaster University Email author 
  • , Luciano MinuzziAffiliated withWomen’s Health Concerns Clinic, St. Joseph’s Healthcare Hamilton, McMaster UniversityMood Disorders Program, Department of Psychiatry and Behavioural Neurosciences, McMaster University

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Abstract

Large-scale clinical and epidemiological studies suggest a link between bipolar disorder (BD) and premenstrual dysphoric disorder (PMDD). However, smaller studies using prospective charting failed to find this association. Here, we report three cases of individuals with BD and comorbid PMDD who responded successfully to adjunctive contraceptive agents in the management of their severe premenstrual symptoms. While controlled trials investigating pharmacological and non-pharmacological treatments are awaited, adjunctive treatment of contraceptive agents and mood stabilizers may be an option in the treatment of comorbid BD and PMDD.

Keywords

Bipolar disorder Contraceptives Premenstrual dysphoric disorder Premenstrual syndrome Treatment