Archives of Women's Mental Health

, Volume 15, Issue 6, pp 413–422

The role of menstrual cycle phase and anxiety sensitivity in catastrophic misinterpretation of physical symptoms during a CO2 challenge

Authors

    • Department of PsychologyUniversity of Vermont
    • Department of Psychiatry and Human BehaviorUniversity of Mississippi Medical Center
  • Kelly J. Rohan
    • Department of PsychologyUniversity of Vermont
  • Michael J. Zvolensky
    • Department of PsychologyUniversity of Houston
Original Article

DOI: 10.1007/s00737-012-0302-2

Cite this article as:
Nillni, Y.I., Rohan, K.J. & Zvolensky, M.J. Arch Womens Ment Health (2012) 15: 413. doi:10.1007/s00737-012-0302-2

Abstract

The current study examined the interactive effects of anxiety sensitivity (AS; fear of anxiety and anxiety-related sensations) and menstrual cycle phase (premenstrual phase vs. follicular phase) on panic-relevant responding (i.e., cognitive and physical panic symptoms, subjective anxiety, and skin conductance level). Women completed a baseline session and underwent a 3-min 10 % CO2-enriched air biological challenge paradigm during her premenstrual and follicular menstrual cycle phases. Participants were 55 women with no current or past history of panic disorder recruited from the general community (Mage = 26.18, SD = 8.9) who completed the biological challenge during both the premenstrual and follicular cycle phases. Results revealed that women higher on AS demonstrated increased cognitive panic symptoms in response to the challenge during the premenstrual phase as compared to the follicular phase, and as compared to women lower on AS assessed in either cycle phase. However, the interaction of AS and menstrual cycle phase did not significantly predict physical panic attack symptoms, subjective ratings of anxiety, or skin conductance level in response to the challenge. Results are discussed in the context of premenstrual exacerbations of cognitive, as opposed to physical, panic attack symptoms for high AS women, and the clinical implications of these findings.

Keywords

Anxiety sensitivityBiological challengeMenstrual cyclePanic disorderPremenstrual phase

Copyright information

© Springer-Verlag 2012