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The role of taurine in renal disorders

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An Erratum to this article was published on 20 December 2013

Abstract

This article examines the actions of taurine on models of renal dysfunction, the potential mechanisms of taurine action and the possible clinical significance of these findings. Our laboratory has written previously on the role of taurine in renal function and we have focused upon the normal physiology of the kidney and on the mechanisms and regulation of the renal transport of taurine. This review is a distinct change of emphasis in that we describe a number of studies which have evaluated various aspects of renal dysfunction, including hypertension and proteinuria, specific glomerular and tubular disorders, acute and chronic renal conditions, urinary tract conditions including infection and nephrolithiasis, and diabetic nephropathy. The subject of chronic kidney disease and renal transplantation will also be examined relative to β amino acid. The studies evaluated will be mainly recent ones, recognizing that older reviews of the role of this taurine in the kidney are available.

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References

  • Abdel-Hamid HZ (2010) Peroxisomal disorders. http://emedicine.medscape.com/article/1177387-overview#a0199. Accessed 11 May 2010

  • Atanassova SS, Panchev P, Ivanova M (2010) Plasma levels and urinary excretion of amino acids by subjects with renal calculi. Amino Acids 38(5):1277–1282

    Article  PubMed  CAS  Google Scholar 

  • Badary OA (1998) Taurine attenuates Fanconi syndrome induced by ifosfamide without compromising its antitumor activity. Oncol Res 10(7):355–360

    PubMed  CAS  Google Scholar 

  • Battaglia FC, Regnault TR (2001) Placental transport and metabolism of amino acids. Placenta 22(2–3):145–161

    Article  PubMed  CAS  Google Scholar 

  • Bergstrom J, Alvestrand A, Furst P, Lindholm B (1989) Sulphur amino acids in plasma and muscle in patients with chronic renal failure: evidence for taurine depletion. J Intern Med 226(3):189–194

    Article  PubMed  CAS  Google Scholar 

  • Bounedjah O, Hamon L, Savarin P, Desforges B, Curmi PA, Pastre D (2012) Macromolecular crowding regulates assembly of mRNA stress granules after osmotic stress: new role for compatible osmolytes. J Biol Chem 287(4):2446–2458

    Article  PubMed  CAS  Google Scholar 

  • Burg MB (1995) Molecular basis of osmotic regulation. Am J Physiol 268(6 Pt 2):F983–F996

    PubMed  CAS  Google Scholar 

  • Buschmann T, Potapova O, Bar-Shira A, Ivanov VN, Fuchs SY, Henderson S, Fried VA, Minamoto T, Alarcon-Vargas D, Pincus MR, Gaarde WA, Holbrook NJ, Shiloh Y, Ronai Z (2001) Jun NH2-terminal kinase phosphorylation of p53 on Thr-81 is important for p53 stabilization and transcriptional activities in response to stress. Mol Cell Biol 21(8):2743–2754

    Article  PubMed  CAS  Google Scholar 

  • Chen H, Condron C, Chen G, Moloney M, Bouchier-Hayes D (2009) Taurine attenuates endothelial cell injury induced by hypoxia–reoxygenation. Paper presented at the 17th international taurine meeting “Taurine: a wonder molecule”, Miami, FL, Dec 14–19, 2009

  • Chesney RW, Carpenter MA, Moxey-Mims M, Nyberg L, Greenfield SP, Hoberman A, Keren R, Matthews R, Matoo TK (2008) Randomized intervention for children with vesicoureteral reflux (RIVUR): background commentary of RIVUR investigators. Pediatrics 122(Suppl 5):S233–S239

    Article  PubMed  Google Scholar 

  • Chesney RW, Han X, Patters AB (2010) Taurine and the renal system. J Biomed Sci 17(Suppl 1):S4

    Article  PubMed  CAS  Google Scholar 

  • Chesney RW, Patters AB, Han X (2011) Taurine and the kidneys. In: El Idrissi A, L’Amoreaux W (eds) Taurine in health and disease. Transworld Research Network, Kerala

    Google Scholar 

  • Chesney RW, Scriver CR, Mohyuddin F (1976) Localization of the membrane defect in transepithelial transport of taurine by parallel studies in vivo and in vitro in hypertaurinuric mice. J Clin Invest 57(1):183–193

    Article  PubMed  CAS  Google Scholar 

  • Clayton PT, Lake BD, Hall NA, Shortland DB, Carruthers RA, Lawson AM (1987) Plasma bile acids in patients with peroxisomal dysfunction syndromes: analysis by capillary gas chromatography–mass spectrometry. Eur J Pediatr 146(2):166–173

    Article  PubMed  CAS  Google Scholar 

  • Condron C, Casey RG, Kehoe S, Toomey D, Creagh T, Bouchier-Hayes DJ (2010) Taurine modulates neutrophil function but potentiates uropathogenic E. coli infection in the murine bladder. Urol Res 38(4):215–222

    Article  PubMed  CAS  Google Scholar 

  • Condron CM, Toomey DM, Casey RG, Creagh T, Bouchier-Hayes DJ (2004) Taurine protects against PMN dysfunction and death in urine. Urol Res 32(5):338–345

    Article  PubMed  CAS  Google Scholar 

  • Coppes MJ, Campbell CE, Williams BR (1993) The role of WT1 in Wilms tumorigenesis. FASEB J 7(10):886–895

    PubMed  CAS  Google Scholar 

  • Cusworth DC, Dent CE (1960) Renal clearances of amino acids in normal adults and in patients with aminoaciduria. Biochem J 74:550–561

    PubMed  CAS  Google Scholar 

  • Dabbagh S, Gusowski N, Chesney R, Falsetti G, Ellis M, Ellis D (1989) Cyclic AMP does not alter taurine accumulation by rat renal brush border membrane vesicles. Biochem Med Metab Biol 42(2):132–145

    Article  PubMed  CAS  Google Scholar 

  • Dabbagh S, Gusowski N, Padilla M, Theissen M, Chesney RW (1990) Perturbation of renal amino acid transport by brush border membrane vesicles in the vitamin D-deficient rat. Biochem Med Metab Biol 44(1):64–76

    Article  PubMed  CAS  Google Scholar 

  • Das J, Ghosh J, Manna P, Sil PC (2010) Taurine protects acetaminophen-induced oxidative damage in mice kidney through APAP urinary excretion and CYP2E1 inactivation. Toxicology 269(1):24–34

    Article  PubMed  CAS  Google Scholar 

  • Das J, Sil PC (2012) Taurine ameliorates alloxan-induced diabetic renal injury, oxidative stress-related signaling pathways and apoptosis in rats. Amino Acids. [Epub ahead of print]

  • Dawson R Jr, Liu S, Jung B, Messina S, Eppler B (2000) Effects of high salt diets and taurine on the development of hypertension in the stroke-prone spontaneously hypertensive rat. Amino Acids 19(3–4):643–665

    Article  PubMed  CAS  Google Scholar 

  • Derijard B, Hibi M, Wu IH, Barrett T, Su B, Deng T, Karin M, Davis RJ (1994) JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. Cell 76(6):1025–1037

    Article  PubMed  CAS  Google Scholar 

  • Desforges B, Savarin P, Bounedjah O, Delga S, Hamon L, Curmi PA, Pastre D (2011) Gap junctions favor normal rat kidney epithelial cell adaptation to chronic hypertonicity. Am J Physiol Cell Physiol 301(3):C705–C716

    Article  PubMed  CAS  Google Scholar 

  • Eldin AA, Shaheen AA, Abd Elgawad HM, Shehata NI (2008) Protective effect of taurine and quercetin against renal dysfunction associated with the combined use of gentamicin and diclofenac. Indian J Biochem Biophys 45(5):332–340

    PubMed  CAS  Google Scholar 

  • Evans RW, Powers RW, Ness RB, Cropcho LJ, Daftary AR, Harger GF, Vergona R, Finegold DN (2003) Maternal and fetal amino acid concentrations and fetal outcomes during pre-eclampsia. Reproduction 125(6):785–790

    Article  PubMed  CAS  Google Scholar 

  • Falk RJ, Jennette JC (1988) Anti-neutrophil cytoplasmic autoantibodies with specificity for myeloperoxidase in patients with systemic vasculitis and idiopathic necrotizing and crescentic glomerulonephritis. N Engl J Med 318(25):1651–1657

    Article  PubMed  CAS  Google Scholar 

  • Ferdinandusse S, Overmars H, Denis S, Waterham HR, Wanders RJ, Vreken P (2001) Plasma analysis of di- and trihydroxycholestanoic acid diastereoisomers in peroxisomal alpha-methylacyl-CoA racemase deficiency. J Lipid Res 42(1):137–141

    PubMed  CAS  Google Scholar 

  • Fleck C, Engelbert K (1998) The hepato-renal syndrome: renal amino acid transport in bile duct ligated rats (DL)—influence of treatment with triiodothyronine or dexamethasone on renal amino acid handling in amino acid loaded rats. Exp Toxicol Pathol 50(4–6):356–364

    Article  PubMed  CAS  Google Scholar 

  • Flora SJ, Pande M, Bhadauria S, Kannan GM (2004) Combined administration of taurine and meso 2,3-dimercaptosuccinic acid in the treatment of chronic lead intoxication in rats. Hum Exp Toxicol 23(4):157–166

    Article  PubMed  CAS  Google Scholar 

  • Foreman JW, Bowring MA, Lee J, States B, Segal S (1987) Effect of cystine dimethylester on renal solute handling and isolated renal tubule transport in the rat: a new model of the Fanconi syndrome. Metabolism 36(12):1185–1191

    Article  PubMed  CAS  Google Scholar 

  • Friedman AL, Jax DK, Chesney RW (1981) Developmental aspects of renal beta-amino acid transport. III. Ontogeny of transport in isolated renal tubule segments. Pediatr Res 15(1):10–13

    Article  PubMed  CAS  Google Scholar 

  • Fuchs SY, Adler V, Buschmann T, Yin Z, Wu X, Jones SN, Ronai Z (1998) JNK targets p53 ubiquitination and degradation in nonstressed cells. Genes Dev 12(17):2658–2663

    Article  PubMed  CAS  Google Scholar 

  • Fuchs SY, Xie B, Adler V, Fried VA, Davis RJ, Ronai Z (1997) c-Jun NH2-terminal kinases target the ubiquitination of their associated transcription factors. J Biol Chem 272(51):32163–32168

    Article  PubMed  CAS  Google Scholar 

  • Gallieni M, Chiarelli G, Olivi L, Cozzolino M, Cusi D (2011) Unsuccessful application of taurolidine in the treatment of fungal peritonitis in peritoneal dialysis. Clin Nephrol 75(1):70–73

    PubMed  CAS  Google Scholar 

  • Gardner RJ, Brown N (1976) Lowe’s syndrome: identification of carriers by lens examination. J Med Genet 13(6):449–454

    Article  PubMed  CAS  Google Scholar 

  • Gines P, Arroyo V (1999) Hepatorenal syndrome. J Am Soc Nephrol 10(8):1833–1839

    PubMed  CAS  Google Scholar 

  • Gomez RA, Tufro-McReddie A, Everett AD, Pentz ES (1993) Ontogeny of renin and AT1 receptor in the rat. Pediatr Nephrol 7(5):635–638

    Article  PubMed  CAS  Google Scholar 

  • Guan X, Dei-Anane G, Liang R, Gross ML, Nickkholgh A, Kern M, Ludwig J, Zeier M, Buchler MW, Schmidt J, Schemmer P (2008) Donor preconditioning with taurine protects kidney grafts from injury after experimental transplantation. J Surg Res 146(1):127–134

    Article  PubMed  CAS  Google Scholar 

  • Gunther R, Silbernagl S, Deetjen P (1979) Maleic acid induced aminoaciduria, studied by free flow micropuncture and continuous microperfusion. Pflugers Arch 382(2):109–114

    PubMed  CAS  Google Scholar 

  • Guz G, Oz E, Lortlar N, Ulusu NN, Nurlu N, Demirogullari B, Omeroglu S, Sert S, Karasu C (2007) The effect of taurine on renal ischemia/reperfusion injury. Amino Acids 32(3):405–411

    Article  PubMed  CAS  Google Scholar 

  • Hagar HH, El Etter E, Arafa M (2006) Taurine attenuates hypertension and renal dysfunction induced by cyclosporine A in rats. Clin Exp Pharmacol Physiol 33(3):189–196

    Article  PubMed  CAS  Google Scholar 

  • Han X, Chesney RW (2003) Regulation of taurine transporter gene (TauT) by WT1. FEBS Lett 540(1–3):71–76

    Article  PubMed  CAS  Google Scholar 

  • Han X, Chesney RW (2005) Regulation of TauT by cisplatin in LLC-PK1 renal cells. Pediatr Nephrol 20(8):1067–1072

    Article  PubMed  CAS  Google Scholar 

  • Han X, Chesney RW (2006) Mechanisms of regulation of taurine transporter activity: a complex interplay of regulatory systems. Adv Exp Med Biol 583:79–90

    Article  PubMed  CAS  Google Scholar 

  • Han X, Chesney RW (2009a) Mechanism of TauT in protecting against cisplatin-induced kidney injury (AKI). Adv Exp Med Biol 643:105–112

    Article  PubMed  CAS  Google Scholar 

  • Han X, Chesney RW (2009b) TauT protects against cisplatin-induced acute kidney injury (AKI) established in a TauT transgenic mice model. Adv Exp Med Biol 643:113–122

    Article  PubMed  CAS  Google Scholar 

  • Han X, Chesney RW (2010) Stress-responsive gene TauT and acute kidney injury. J Biomed Sci 17(Suppl 1):S28

    Article  PubMed  CAS  Google Scholar 

  • Han X, Patters AB, Jones DP, Zelikovic I, Chesney RW (2006) The taurine transporter: mechanisms of regulation. Acta Physiol (Oxf) 187(1–2):61–73

    Article  CAS  Google Scholar 

  • Han X, Yue J, Chesney RW (2009) Functional TauT protects against acute kidney injury. J Am Soc Nephrol 20(6):1323–1332

    Article  PubMed  CAS  Google Scholar 

  • Handler JS, Kwon HM (1993) Regulation of renal cell organic osmolyte transport by tonicity. Am J Physiol 265(6 Pt 1):C1449–C1455

    PubMed  CAS  Google Scholar 

  • Hansen SH (2001) The role of taurine in diabetes and the development of diabetic complications. Diabetes Metab Res Rev 17(5):330–346

    Article  PubMed  CAS  Google Scholar 

  • Higo S, Miyata S, Jiang QY, Kitazawa R, Kitazawa S, Kasuga M (2008) Taurine administration after appearance of proteinuria retards progression of diabetic nephropathy in rats. Kobe J Med Sci 54(1):E35–E45

    PubMed  Google Scholar 

  • Hu J, Xu X, Yang J, Wu G, Sun C, Lv Q (2009) Antihypertensive effect of taurine in rat. Adv Exp Med Biol 643:75–84

    Article  PubMed  CAS  Google Scholar 

  • Huang JS, Chuang LY, Guh JY, Huang YJ (2009) Effects of nitric oxide and antioxidants on advanced glycation end products-induced hypertrophic growth in human renal tubular cells. Toxicol Sci 111(1):109–119

    Article  PubMed  CAS  Google Scholar 

  • Huang JS, Chuang LY, Guh JY, Huang YJ, Hsu MS (2007) Antioxidants attenuate high glucose-induced hypertrophic growth in renal tubular epithelial cells. Am J Physiol Renal Physiol 293(4):F1072–F1082

    Article  PubMed  CAS  Google Scholar 

  • Huang JS, Chuang LY, Guh JY, Yang YL, Hsu MS (2008) Effect of taurine on advanced glycation end products-induced hypertrophy in renal tubular epithelial cells. Toxicol Appl Pharmacol 233(2):220–226

    Article  PubMed  CAS  Google Scholar 

  • Ito T, Fujio Y, Schaffer SW, Azuma J (2009) Involvement of transcriptional factor TonEBP in the regulation of the taurine transporter in the cardiomyocyte. Adv Exp Med Biol 643:523–532

    Article  PubMed  CAS  Google Scholar 

  • Jeon SH, Park HM, Kim SJ, Lee MY, Kim GB, Rahman MM, Woo JN, Kim IS, Kim JS, Kang HS (2010) Taurine reduces FK506-induced generation of ROS and activation of JNK and Bax in Madin Darby canine kidney cells. Hum Exp Toxicol 29(8):627–633

    Article  PubMed  CAS  Google Scholar 

  • Jones DP, Chesney RW (1992) Development of tubular function. Clin Perinatol 19(1):33–57

    PubMed  CAS  Google Scholar 

  • Jung BC, Laidlaw SA, Kopple JD (1991) Taurine levels in plasma and blood cells in patients undergoing routine maintenance hemodialysis. Am J Kidney Dis 18(1):74–79

    PubMed  CAS  Google Scholar 

  • Kim CD, Kim EY, Yoo H, Lee JW, Ryu do H, Noh DW, Park SH, Kim YL, Hwang GS, Kwon TH (2010) Metabonomic analysis of serum metabolites in kidney transplant recipients with cyclosporine A- or tacrolimus-based immunosuppression. Transplantation 90(7):748–756

    Article  PubMed  CAS  Google Scholar 

  • Klebanoff SJ (2005) Myeloperoxidase: friend and foe. J Leukoc Biol 77(5):598–625

    Article  PubMed  CAS  Google Scholar 

  • Koeners MP, Braam B, van der Giezen DM, Goldschmeding R, Joles JA (2010) Perinatal micronutrient supplements ameliorate hypertension and proteinuria in adult fawn-hooded hypertensive rats. Am J Hypertens 23(7):802–808

    Article  PubMed  CAS  Google Scholar 

  • Koya D, Hayashi K, Kitada M, Kashiwagi A, Kikkawa R, Haneda M (2003) Effects of antioxidants in diabetes-induced oxidative stress in the glomeruli of diabetic rats. J Am Soc Nephrol 14(8 Suppl 3):S250–S253

    Article  PubMed  CAS  Google Scholar 

  • Kreidberg JA, Sariola H, Loring JM, Maeda M, Pelletier J, Housman D, Jaenisch R (1993) WT-1 is required for early kidney development. Cell 74(4):679–691

    Article  PubMed  CAS  Google Scholar 

  • Kuligowski MP, Kitching AR, Hickey MJ (2006) Leukocyte recruitment to the inflamed glomerulus: a critical role for platelet-derived P-selectin in the absence of rolling. J Immunol 176(11):6991–6999

    PubMed  CAS  Google Scholar 

  • Lawson AM, Madigan MJ, Shortland D, Clayton PT (1986) Rapid diagnosis of Zellweger syndrome and infantile Refsum’s disease by fast atom bombardment—mass spectrometry of urine bile salts. Clin Chim Acta 161(2):221–231

    Article  PubMed  CAS  Google Scholar 

  • Li CY, Deng YL, Sun BH (2009) Taurine protected kidney from oxidative injury through mitochondrial-linked pathway in a rat model of nephrolithiasis. Urol Res 37(4):211–220

    Article  PubMed  CAS  Google Scholar 

  • Lian X, Yang L, Chen Q (2003) Effects of taurine on platelet activating factor in rats with Masugi glomerulonephritis. J Chinese Microcirc 7(3):151–153

    Google Scholar 

  • Lin S, Yang J, Wu G, Liu M, Luan X, Lv Q, Zhao H, Hu J (2010) Preventive effect of taurine on experimental type II diabetic nephropathy. J Biomed Sci 17(Suppl 1):S46

    Article  PubMed  CAS  Google Scholar 

  • Lindheimer MD, Cunnigham FG, Roberts JM, Chesney L (1999) Hypertension in pregnancy. Chesley’s hypertensive disorders in pregnancy. Appleton & Lange, Stamford

  • MacLellan DL, Mataija D, Doucette A, Huang W, Langlois C, Trottier G, Burton IW, Walter JA, Karakach TK (2011) Alterations in urinary metabolites due to unilateral ureteral obstruction in a rodent model. Mol BioSyst 7(7):2181–2188

    Article  PubMed  CAS  Google Scholar 

  • McKusick VA (2011) #214100 Zellweger syndrome; ZS. http://us-east.omim.org/entry/214100. Accessed 11 Oct 2011

  • Michalk DV, Hoffmann B, Minor T (2003) Taurine reduces renal ischemia/reperfusion injury in the rat. Adv Exp Med Biol 526:49–56

    Article  PubMed  CAS  Google Scholar 

  • Moss AH, Gabow PA, Kaehny WD, Goodman SI, Haut LL (1980) Fanconi’s syndrome and distal renal tubular acidosis after glue sniffing. Ann Intern Med 92(1):69–70

    PubMed  CAS  Google Scholar 

  • Mozaffari MS (2003) Taurine modulation of renal excretory function. Thai J Physiol Sci 16(3):83–90

    Google Scholar 

  • Mozaffari MS, Abdelsayed R, Patel C, Wimborne H, Liu JY, Schaffer SW (2010) Differential effects of taurine treatment and taurine deficiency on the outcome of renal ischemia reperfusion injury. J Biomed Sci 17(Suppl 1):S32

    Article  PubMed  CAS  Google Scholar 

  • Mozaffari MS, Miyata N, Schaffer SW (2003) Effects of taurine and enalapril on kidney function of the hypertensive glucose-intolerant rat. Am J Hypertens 16(8):673–680

    Article  PubMed  CAS  Google Scholar 

  • Mozaffari MS, Patel C, Abdelsayed R, Schaffer SW (2006) Accelerated NaCl-induced hypertension in taurine-deficient rat: role of renal function. Kidney Int 70(2):329–337

    Article  PubMed  CAS  Google Scholar 

  • Mozaffari MS, Schaffer D (2001) Taurine modulates arginine vasopressin-mediated regulation of renal function. J Cardiovasc Pharmacol 37(6):742–750

    Article  PubMed  CAS  Google Scholar 

  • Mozaffari MS, Schaffer SW (2002) Chronic taurine treatment ameliorates reduction in saline-induced diuresis and natriuresis. Kidney Int 61(5):1750–1759

    Article  PubMed  CAS  Google Scholar 

  • Mozaffari MS, Warren BK, Azuma J, Schaffer SW (1998) Renal excretory responses of taurine-depleted rats to hypotonic and hypertonic saline infusion. Amino Acids 15(1–2):109–116

    Article  PubMed  CAS  Google Scholar 

  • Mukherjee S (2011) Hepatorenal syndrome. http://emedicine.medscape.com/article/178208-overview. Accessed 25 Oct 2011

  • Nagl M, Pfausler B, Schmutzhard E, Fille M, Gottardi W (1998) Tolerance and bactericidal action of N-chlorotaurine in a urinary tract infection by an omniresistant Pseudomonas aeruginosa. Zentralbl Bakteriol 288(2):217–223

    Article  PubMed  CAS  Google Scholar 

  • Nara Y, Yamori Y, Lovenberg W (1978) Effect of dietary taurine on blood pressure in spontaneously hypertensive rats. Biochem Pharmacol 27(23):2689–2692

    Article  PubMed  CAS  Google Scholar 

  • Ng CK, Chan MH, Tai MH, Lam CW (2007) Hepatorenal syndrome. Clin Biochem Rev 28(1):11–17

    PubMed  Google Scholar 

  • Nishimura H, Ikehara O, Naito T, Higuchi C, Sanaka T (2009) Evaluation of taurine as an osmotic agent for peritoneal dialysis solution. Perit Dial Int 29(2):204–216

    PubMed  CAS  Google Scholar 

  • Odobasic D, Kitching AR, Semple TJ, Holdsworth SR (2007) Endogenous myeloperoxidase promotes neutrophil-mediated renal injury, but attenuates T cell immunity inducing crescentic glomerulonephritis. J Am Soc Nephrol 18(3):760–770

    Article  PubMed  CAS  Google Scholar 

  • Parikh CR, Devarajan P, Zappitelli M, Sint K, Thiessen-Philbrook H, Li S, Kim RW, Koyner JL, Coca SG, Edelstein CL, Shlipak MG, Garg AX, Krawczeski CD (2011) Postoperative biomarkers predict acute kidney injury and poor outcomes after adult cardiac surgery. J Am Soc Nephrol 22(9):1748–1757

    Article  PubMed  CAS  Google Scholar 

  • Perfumo F, Canepa A, Divino Filho JC, Nilsson E, Carrea A, Verrina E, Gusmano R, Bergstrom J (1994) Muscle and plasma amino acids and nutritional status in kidney-transplanted children. Nephrol Dial Transplant 9(12):1778–1785

    PubMed  CAS  Google Scholar 

  • Pritchard-Jones K, Fleming S, Davidson D, Bickmore W, Porteous D, Gosden C, Bard J, Buckler A, Pelletier J, Housman D et al (1990) The candidate Wilms’ tumour gene is involved in genitourinary development. Nature 346(6280):194–197

    Article  PubMed  CAS  Google Scholar 

  • Romick-Rosendale LE, Brunner HI, Bennett MR, Mina R, Nelson S, Petri M, Kiani A, Devarajan P, Kennedy MA (2011) Identification of urinary metabolites that distinguish membranous lupus nephritis from proliferative lupus nephritis and focal segmental glomerulosclerosis. Arthritis Res Ther 13(6):R199

    Article  PubMed  Google Scholar 

  • Rovetta F, Stacchiotti A, Consiglio A, Cadei M, Grigolato PG, Lavazza A, Rezzani R, Aleo MF (2012) ER signaling regulation drives the switch between autophagy and apoptosis in NRK-52E cells exposed to cisplatin. Exp Cell Res 318(3):238–250

    Article  PubMed  CAS  Google Scholar 

  • Roy A, Manna P, Sil PC (2009) Prophylactic role of taurine on arsenic mediated oxidative renal dysfunction via MAPKs/NF-kappaB and mitochondria dependent pathways. Free Radic Res 43(10):995–1007

    Article  PubMed  CAS  Google Scholar 

  • Roysommuti S, Malila P, Jirakulsomchok D, Wyss JM (2010a) Adult renal function is modified by perinatal taurine status in conscious male rats. J Biomed Sci 17(Suppl 1):S31

    Article  PubMed  CAS  Google Scholar 

  • Roysommuti S, Malila P, Lerdweeraphon W, Jirakulsomchok D, Wyss JM (2010b) Perinatal taurine exposure alters renal potassium excretion mechanisms in adult conscious rats. J Biomed Sci 17(Suppl 1):S29

    Article  PubMed  CAS  Google Scholar 

  • Roysommuti S, Suwanich A, Lerdweeraphon W, Thaeomor A, Jirakulsomchok D, Wyss JM (2009) Sex dependent effects of perinatal taurine exposure on the arterial pressure control in adult offspring. Adv Exp Med Biol 643:135–144

    Article  PubMed  CAS  Google Scholar 

  • Saleem S, Dai Z, Coelho SN, Konieczny BT, Assmann KJ, Baddoura FK, Lakkis FG (1998) IL-4 is an endogenous inhibitor of neutrophil influx and subsequent pathology in acute antibody-mediated inflammation. J Immunol 160(2):979–984

    PubMed  CAS  Google Scholar 

  • Satake M, Ikarashi N, Kagami M, Ogiue N, Toda T, Kobayashi Y, Ochiai W, Sugiyama K (2010) Increases in the expression levels of aquaporin-2 and aquaporin-3 in the renal collecting tubules alleviate dehydration associated with polyuria in diabetes mellitus. Biol Pharm Bull 33(12):1965–1970

    Article  PubMed  CAS  Google Scholar 

  • Sato Y, Ogata E, Fujita T (1991) Hypotensive action of taurine in DOCA-salt rats—involvement of sympathoadrenal inhibition and endogenous opiate. Jpn Circ J 55(5):500–508

    Article  PubMed  CAS  Google Scholar 

  • Satoh H, Kang J (2009) Modulation by taurine of human arterial stiffness and wave reflection. Adv Exp Med Biol 643:47–55

    Article  PubMed  CAS  Google Scholar 

  • Schmitz V, Klawitter J, Bendrick-Peart J, Schoening W, Puhl G, Haschke M, Klawitter J, Consoer J, Rivard CJ, Chan L, Tran ZV, Leibfritz D, Christians U (2009) Metabolic profiles in urine reflect nephrotoxicity of sirolimus and cyclosporine following rat kidney transplantation. Nephron Exp Nephrol 111(4):e80–e91

    Article  PubMed  CAS  Google Scholar 

  • Schoffl I, Kothmann JF, Schoffl V, Rupprecht HD, Rupprecht T (2011) “Vodka energy”: too much for the adolescent nephron? Pediatrics 128(1):e227–e231

    Article  PubMed  Google Scholar 

  • Shah CB, Mittelman MW, Costerton JW, Parenteau S, Pelak M, Arsenault R, Mermel LA (2002) Antimicrobial activity of a novel catheter lock solution. Antimicrob Agents Chemother 46(6):1674–1679

    Article  PubMed  CAS  Google Scholar 

  • Shi X, Yao D, Chen C (2012) Identification of N-acetyltaurine as a novel metabolite of ethanol through metabolomics-guided biochemical analysis. J Biol Chem 287(9):6336–6349

    Google Scholar 

  • Stein CS, Yancey PH, Martins I, Sigmund RD, Stokes JB, Davidson BL (2010) Osmoregulation of ceroid neuronal lipofuscinosis type 3 in the renal medulla. Am J Physiol Cell Physiol 298(6):C1388–C1400

    Article  PubMed  CAS  Google Scholar 

  • Suliman ME, Barany P, Filho JC, Lindholm B, Bergstrom J (2002a) Accumulation of taurine in patients with renal failure. Nephrol Dial Transplant 17(3):528–529

    Article  PubMed  Google Scholar 

  • Suliman ME, Stenvinkel P, Heimburger O, Barany P, Lindholm B, Bergstrom J (2002b) Plasma sulfur amino acids in relation to cardiovascular disease, nutritional status, and diabetes mellitus in patients with chronic renal failure at start of dialysis therapy. Am J Kidney Dis 40(3):480–488

    Article  PubMed  CAS  Google Scholar 

  • Thaeomor A, Wyss JM, Jirakulsomchok D, Roysommuti S (2010) High sugar intake via the renin–angiotensin system blunts the baroreceptor reflex in adult rats that were perinatally depleted of taurine. J Biomed Sci 17(Suppl 1):S30

    Article  PubMed  CAS  Google Scholar 

  • Tipping PG, Huang XR, Qi M, Van GY, Tang WW (1998) Crescentic glomerulonephritis in CD4- and CD8-deficient mice. Requirement for CD4 but not CD8 cells. Am J Pathol 152(6):1541–1548

    PubMed  CAS  Google Scholar 

  • Trachtman H, Del Pizzo R, Futterweit S, Levine D, Rao PS, Valderrama E, Sturman JA (1992) Taurine attenuates renal disease in chronic puromycin aminonucleoside nephropathy. Am J Physiol 262(1 Pt 2):F117–F123

    PubMed  CAS  Google Scholar 

  • Trachtman H, Futterweit S, Maesaka J, Ma C, Valderrama E, Fuchs A, Tarectecan AA, Rao PS, Sturman JA, Boles TH et al (1995) Taurine ameliorates chronic streptozocin-induced diabetic nephropathy in rats. Am J Physiol 269(3 Pt 2):F429–F438

    PubMed  CAS  Google Scholar 

  • Tyagi R, Rana P, Gupta M, Khan AR, Bhatnagar D, Bhalla PJ, Chaturvedi S, Tripathi RP, Khushu S (2011) Differential biochemical response of rat kidney towards low and high doses of NiCl(2) as revealed by NMR spectroscopy. J Appl Toxicol. doi:10.1002/jat.1730. [Epub ahead of print]

  • Une M, Tazawa Y, Tada K, Hoshita T (1987) Occurrence of both (25R)- and (25S)-3 alpha, 7 alpha, 12 alpha-trihydroxy-5 beta-cholestanoic acids in urine from an infant with Zellweger’s syndrome. J Biochem 102(6):1525–1530

    PubMed  CAS  Google Scholar 

  • United States Renal Data System (2011) http://www.usrds.org/

  • Venkatesan N, Venkatesan P, Karthikeyan J, Arumugam V (1997) Protection by taurine against adriamycin-induced proteinuria and hyperlipidemia in rats. Proc Soc Exp Biol Med 215(2):158–164

    PubMed  CAS  Google Scholar 

  • Wang L, Zhang L, Yu Y, Wang Y, Niu N (2008) The protective effects of taurine against early renal injury in STZ-induced diabetic rats, correlated with inhibition of renal LOX-1-mediated ICAM-1 expression. Ren Fail 30(8):763–771

    Article  PubMed  CAS  Google Scholar 

  • Wang SS, Devuyst O, Courtoy PJ, Wang XT, Wang H, Wang Y, Thakker RV, Guggino S, Guggino WB (2000) Mice lacking renal chloride channel, CLC-5, are a model for Dent’s disease, a nephrolithiasis disorder associated with defective receptor-mediated endocytosis. Hum Mol Genet 9(20):2937–2945

    Article  PubMed  CAS  Google Scholar 

  • Wingenfeld P, Gehrmann U, Strubind S, Minor T, Isselhard W, Michalk DV (1996) Long-lasting hypoxic preservation of porcine kidney cells. Beneficial effect of taurine on viability and metabolism in a simplified transplantation model. Adv Exp Med Biol 403:203–212

    PubMed  CAS  Google Scholar 

  • Wingenfeld P, Minor T, Gehrmann U, Strubind S, Isselhard W, Michalk D (1995) Hypoxic cellular deterioration and its prevention by the amino acid taurine in a transplantation model with renal tubular cells (LLC-PK1). In Vitro Cell Dev Biol Anim 31(7):483–486

    Article  PubMed  CAS  Google Scholar 

  • Winiarska K, Szymanski K, Gorniak P, Dudziak M, Bryla J (2009) Hypoglycaemic, antioxidative and nephroprotective effects of taurine in alloxan diabetic rabbits. Biochimie 91(2):261–270

    Article  PubMed  CAS  Google Scholar 

  • Xiong X, Demianczuk NN, Saunders LD, Wang FL, Fraser WD (2002) Impact of preeclampsia and gestational hypertension on birth weight by gestational age. Am J Epidemiol 155(3):203–209

    Article  PubMed  Google Scholar 

  • Yao HT, Lin P, Chang YW, Chen CT, Chiang MT, Chang L, Kuo YC, Tsai HT, Yeh TK (2009) Effect of taurine supplementation on cytochrome P450 2E1 and oxidative stress in the liver and kidneys of rats with streptozotocin-induced diabetes. Food Chem Toxicol 47(7):1703–1709

    Article  PubMed  CAS  Google Scholar 

  • Zelikovic I, Chesney RW (1989a) Ionic requirements for amino acid transport. Am J Kidney Dis 14(4):313–316

    PubMed  CAS  Google Scholar 

  • Zelikovic I, Chesney RW (1989b) Sodium-coupled amino acid transport in renal tubule. Kidney Int 36(3):351–359

    Article  PubMed  CAS  Google Scholar 

  • Zelikovic I, Chesney RW, Friedman AL, Ahlfors CE (1990) Taurine depletion in very low birth weight infants receiving prolonged total parenteral nutrition: role of renal immaturity. J Pediatr 116(2):301–306

    Article  PubMed  CAS  Google Scholar 

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Acknowledgments

The authors are grateful to Andrea Patters for assistance with the manuscript.

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  1. Department of Pediatrics, The University of Tennessee Health Science Center, and the Children’s Foundation Research Institute at Le Bonheur Children’s Hospital, Memphis, TN, 38103, USA

    Xiaobin Han & Russell W. Chesney

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  1. Xiaobin Han
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  2. Russell W. Chesney
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Correspondence to Russell W. Chesney.

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An erratum to this article is available at http://dx.doi.org/10.1007/s00726-013-1640-8.

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Han, X., Chesney, R.W. The role of taurine in renal disorders. Amino Acids 43, 2249–2263 (2012). https://doi.org/10.1007/s00726-012-1314-y

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