Minireview Article

Amino Acids

, Volume 39, Issue 1, pp 45-57

Nucleobase-containing peptides: an overview of their characteristic features and applications

  • Giovanni N. RovielloAffiliated withIstituto di Biostrutture e Bioimmagini, Consiglio Nazionale delle Ricerche
  • , Ettore BenedettiAffiliated withDepartment of Scienze Biologiche sez. Biostrutture, Università degli Studi di Napoli ‘Federico II’ Email author 
  • , Carlo PedoneAffiliated withIstituto di Biostrutture e Bioimmagini, Consiglio Nazionale delle Ricerche
  • , Enrico M. BucciAffiliated withIstituto di Biostrutture e Bioimmagini, Consiglio Nazionale delle Ricerche

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Abstract

Reports on nucleobase-containing chiral peptides (both natural and artificial) and achiral pseudopeptides are reviewed. Their synthesis, structural features, DNA and RNA-binding ability, as well as some other interesting applications which make them promising diagnostic/therapeutic agents of great importance in many areas of biology and therapy are taken into critical consideration.

Keywords

Nucleobase Peptide Nucleopeptide Nucleic acid