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Effect of Functional Group and Surface Charge of PEG and Dextran-Coated USPIO as a Contrast Agent in MRI on Relaxivity Constant

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Abstract

The challenges in molecular imaging are focused on the development of novel contrast agents with much lower relaxation times. Ultrasmall superparamagnetic iron oxide nanoparticles known as USPIO have been used for a variety of applications such as imaging of cancer, apoptosis, and hyperthermia providing higher signal changes based on \(T_{2}^{*}\) weighted susceptibility effects. Although many studies had been performed on USPIO there is still a lack of data on the effects of the physicochemical properties of these nanoparticles (NP) such as hydrodynamic size, surface charge and type of functional groups, which may alter the relaxivity of these NPs. The aim of this study was to evaluate the effect of different functional groups and surface charges of PEGylated and dextran-coated NPs on their magnetic properties. All relaxometry studies were performed using a 3-T magnetic resonance imaging. Our results showed that the impact of charge on magnetic properties is much higher than that of coating thickness. In this respect, particles with positive surface charges showed higher r 2/r 1 ratios.

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Acknowledgments

We thank Micromod Company for their supports in terms of providing nanoparticles and the quantitative analysis of the particles. Council of Research of Tehran University of Medical Sciences (TUMS), Tehran, Iran, supported this work.

Conflict of Interest

The authors declare that they have no conflict of interest.

Author information

Authors and Affiliations

  1. Biomolecular Imaging Analysis Group (BIAG), Research Center for Molecular and Cellular Imaging (RCMCI), Tehran University of Medical Sciences, Tehran, Iran

    Nastaran Najafian, Farzaneh Hajesmaeelzadeh & Mohammad Ali Oghabian

  2. Department of Medical Physics and Biomedical Engineering, Faculty of Medicine, Tehran University of Medical Science, Tehran, Iran

    Nastaran Najafian, Farzaneh Hajesmaeelzadeh, Afsaneh Lahooti & Mohammad Ali Oghabian

  3. Radiation Application Research School, Nuclear Science and Technology Research Institute (NSTRI), Tehran, Iran

    Saeed Shanehsazzadeh

  4. Micromod Partikeltechnologie GmbH, Friedrich-Barnewitz-Str. 4, 18119, Rostock, Germany

    Cordula Gruettner

Authors
  1. Nastaran Najafian
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  2. Saeed Shanehsazzadeh
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  3. Farzaneh Hajesmaeelzadeh
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  4. Afsaneh Lahooti
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  5. Cordula Gruettner
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  6. Mohammad Ali Oghabian
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Correspondence to Mohammad Ali Oghabian.

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Najafian, N., Shanehsazzadeh, S., Hajesmaeelzadeh, F. et al. Effect of Functional Group and Surface Charge of PEG and Dextran-Coated USPIO as a Contrast Agent in MRI on Relaxivity Constant. Appl Magn Reson 46, 685–692 (2015). https://doi.org/10.1007/s00723-015-0667-2

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  • DOI: https://doi.org/10.1007/s00723-015-0667-2

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