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Solvent-free multicomponent assembling of isatins, malononitrile, and dimedone: fast and efficient way to functionalized spirooxindole system

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Abstract

Solvent-free sodium acetate catalyzed multicomponent reaction of isatins, malononitrile, and dimedone initiated by grinding in mortar results in the fast and efficient formation of substituted spirooxindoles in 90–99 % yields. The developed solvent-free fast multicomponent approach to the substituted spirooxindoles—the pharmacologically perspective substances with spasmolytic, diuretic, anticoagulant, anticancer, and antianaphylactic activities—is beneficial from the viewpoint of diversity-oriented large-scale processes and represents fast efficient and environmentally benign solvent-free synthetic concept for multicomponent reactions strategy.

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Acknowledgments

The authors gratefully acknowledge the financial support of the Russian Foundation for Basic Research (Project No. 13-03-00096a).

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Authors and Affiliations

  1. N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation

    Michail N. Elinson, Fedor V. Ryzhkov & Mikhail P. Egorov

  2. A. V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences, Moscow, Russian Federation

    Tatiana A. Zaimovskaya

Authors
  1. Michail N. Elinson
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  2. Fedor V. Ryzhkov
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  3. Tatiana A. Zaimovskaya
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  4. Mikhail P. Egorov
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Correspondence to Michail N. Elinson.

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Elinson, M.N., Ryzhkov, F.V., Zaimovskaya, T.A. et al. Solvent-free multicomponent assembling of isatins, malononitrile, and dimedone: fast and efficient way to functionalized spirooxindole system. Monatsh Chem 147, 755–760 (2016). https://doi.org/10.1007/s00706-015-1617-2

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  • DOI: https://doi.org/10.1007/s00706-015-1617-2

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