Library synthesis of cardiomyogenesis inducing compounds using an efficient two-step-one-flow process
- First Online:
- Cite this article as:
- Schön, M., Dreier, D., Schnürch, M. et al. Monatsh Chem (2016) 147: 523. doi:10.1007/s00706-015-1605-6
- 212 Downloads
Within this work we telescoped a batch laboratory scale synthesis towards a two-step-one-flow process to synthesize cardiomyogenesis inducing compounds (4,6-diaminopyrimidines) in continuous manner. Special attention was put on a quick and robust screening protocol and subsequent UHPLC analysis. Finally, the robustness of the method was proven by the multi-gram synthesis of VUT-MK142 using a laboratory scale continuous flow reactor, enabling to deliver enough material for extensive biological testing.