Improved and scalable synthesis of building blocks for the modular synthesis of teraryl-based alpha-helix mimetics
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- Trobe, M. & Breinbauer, R. Monatsh Chem (2016) 147: 509. doi:10.1007/s00706-015-1599-0
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The modular synthesis of teraryl-based alpha-helix mimetics can be accomplished by sequential Suzuki-couplings of arylboronic acid building blocks with 4-iodophenyltriflate core-fragments. We report about new synthetic accesses to core fragments featuring the side chains of Leu, Lys, Cys, Glu, Gln, Ser, and Thr starting from simple phenol precursors.