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Tetradentate hydrazone metal complexes derived from cefazolin and 2,6-diacetylpyridine hydrazide: synthesis, characterization, and antibacterial activity

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Abstract

Tetradentate metal(II) coordination compounds of cefazolin 2,6-diacetylpyridinehydrazone ligand HL derived from the condensation of cefazolin antibiotic with 2,6-diacetylpyridine hydrazide were synthesized. The ligand and mononuclear [ML(H2O)2][PF6] (M = Mn2+, Co2+, Ni2+, Zn2+) complexes were characterized by elemental and thermal analysis, molar conductance and magnetic susceptibility measurements, electronic, FT-IR, 1H NMR, and molecular modeling studies. The ligand behaves as a monoanionic tetradentate NNOO chelating agent. The biological applications of complexes have been studied on two bacteria strains (Escherichia coli and Staphylococcus aureus) by agar disk diffusion method.

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Acknowledgments

We are grateful to Comision de Investigación from the Universidad de Oriente (UDO) and Universidad de Playa Ancha (UPLA) for the financial support.

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Authors and Affiliations

  1. Departamento de Química, Universidad de Oriente, Cumaná, Venezuela

    Juan R. Anacona & Gregory Calvo

  2. Facultad de Ciencias Naturales y Exactas, Universidad de Playa Ancha, Valparaíso, Chile

    Juan Camus

Authors
  1. Juan R. Anacona
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  2. Gregory Calvo
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  3. Juan Camus
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Correspondence to Juan R. Anacona.

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Anacona, J.R., Calvo, G. & Camus, J. Tetradentate hydrazone metal complexes derived from cefazolin and 2,6-diacetylpyridine hydrazide: synthesis, characterization, and antibacterial activity. Monatsh Chem 147, 725–733 (2016). https://doi.org/10.1007/s00706-015-1585-6

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  • DOI: https://doi.org/10.1007/s00706-015-1585-6

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