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Building a library of monofluorinated anilino-methylidenes and spectroscopic studies of their properties

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Abstract

The synthesis of monofluorinated anilinomethylidenes is described. These compounds can serve as building blocks for biologically active fluoroquinolones. The structures of the target compounds have been proved by 1H, 13C, IR, UV, and HR-MS analysis. In addition, 19F NMR spectra of the products were recorded to study the influence of the fluorine atom on the aminomethylidene substituent.

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Acknowledgments

Authors are grateful to the Slovak Research and Development Agency for financial support under contracts No. APVV-0038-11, No. APVV-0339-10, No. APVV-0516-12 and to the Scientific Grant Agency of the Slovak Republic (Project VEGA/1/0660/11).

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Authors and Affiliations

  1. Department of Organic Chemistry, Institute of Organic Chemistry, Catalysis and Petrochemistry, Faculty of Chemical and Food Technology, Slovak University of Technology, Radlinského 9, 812 37, Bratislava, Slovakia

    Kristína Plevová, Miroslava Škodová & Viktor Milata

  2. Department of Physical Chemistry, Institute of Physical Chemistry and Chemical Physics, Faculty of Chemical and Food Technology, Slovak University of Technology, Radlinského 9, 812 37, Bratislava, Slovakia

    Sandra Dorotíková, Dana Dvoranová & Vlasta Brezová

  3. Department of Chemical Theory of Drugs, Faculty of Pharmacy, Comenius University in Bratislava, Kalinčiakova Street 8, 832 32, Bratislava, Slovakia

    Janka Kubincová & Ferdinand Devínsky

Authors
  1. Kristína Plevová
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  2. Sandra Dorotíková
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  3. Miroslava Škodová
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  4. Dana Dvoranová
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  5. Vlasta Brezová
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  6. Viktor Milata
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  7. Janka Kubincová
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  8. Ferdinand Devínsky
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Corresponding author

Correspondence to Viktor Milata.

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Plevová, K., Dorotíková, S., Škodová, M. et al. Building a library of monofluorinated anilino-methylidenes and spectroscopic studies of their properties. Monatsh Chem 146, 291–302 (2015). https://doi.org/10.1007/s00706-014-1337-z

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  • DOI: https://doi.org/10.1007/s00706-014-1337-z

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