Original Paper

Monatshefte für Chemie - Chemical Monthly

, Volume 141, Issue 8, pp 883-888

First online:

A facile and expeditious approach for the synthesis of 2-azetidinone derivatives via a multicomponent reaction

  • Rangappa S. KeriAffiliated withP.G. Department of Studies in Chemistry, Karnatak University
  • , Kallappa M. HosamaniAffiliated withP.G. Department of Studies in Chemistry, Karnatak University Email author 

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New organic reactions allow chemical transformations which were previously unknown. Therefore, new reactions are important contributions to progress in the field of organic synthesis. Herein, we are reporting a simple, one-pot, efficient three-component synthesis of novel 3-chloro-4-[4-(2-oxo-2H-chromen-4-ylmethoxy)phenyl]-1-phenylazetidin-2-one derivatives using 4-(2-oxo-2H-chromen-4-ylmethoxy)benzaldehydes, anilines, and chloroacetyl chloride in the presence of triethyl amine as a catalyst under different conditions. Taking into account environmental and economic considerations, the protocol presented here has the merits of simple operation, convenient work-up, being environmentally benign, and providing good yields. The synthesized compounds were characterized by IR, 1H NMR, 13C NMR, MS, and elemental analysis.

Graphical Abstract



Multicomponent reaction One-pot synthesis Coumarin 2-Azetidinones