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One-pot three-component Biginelli-type reaction catalyzed by ionic liquids in aqueous media

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Abstract

For the first time, 3,4-dihydropyrimidin-2(1H)-one and 3,4-dihydropyrimidin-2(1H)-thione derivatives have been synthesized in good yields by a modified Biginelli-type reaction with dicationic acidic ionic liquids as catalysts. The products could be separated simply from the catalyst–water system, and the catalysts could be reused at least six times without noticeably reducing catalytic activity.

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Acknowledgments

We are grateful to the Education Commission of Jiangsu Province (07KJD530238), Jiangsu Provincial Key Laboratory of Coast Wetland Bioresource and Environment Protection (JLCBE09023), and Professional Elite Foundation of Yancheng Normal University for financial support.

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Authors and Affiliations

  1. Jiangsu Provincial Key Laboratory of Coast Wetland Bioresource and Environment Protection, Yancheng, 224002, People’s Republic of China

    Dong Fang & Dai-zhen Zhang

  2. School of Chemical Engineering, Nanjing University of Science and Technology, Nanjing, 210094, People’s Republic of China

    Dong Fang & Zu-liang Liu

Authors
  1. Dong Fang
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  2. Dai-zhen Zhang
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  3. Zu-liang Liu
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Correspondence to Dong Fang.

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Fang, D., Zhang, Dz. & Liu, Zl. One-pot three-component Biginelli-type reaction catalyzed by ionic liquids in aqueous media. Monatsh Chem 141, 419–423 (2010). https://doi.org/10.1007/s00706-010-0271-y

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  • DOI: https://doi.org/10.1007/s00706-010-0271-y

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