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Synthesis, Reactions, and Pharmacological Activities of Some Pyrimidines Using (N-Methylindolyl)acetic Acid as Synthon

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Summary.

A series of pyrimidinones, thienopyrimidines, and their derivatives were synthesized using N-methylindolyl acetic acid as a starting material. Sixteen new heterocyclics containing a pyrimidine ring were thus prepared. The pharmacological screening showed that many of these compounds have good analgesic and antiparkinsonian activities comparable to Voltarene® and Benzatropine® as reference drugs. The structure assignments of the new compounds based on chemical and spectroscopic evidence. The detailed synthesis, spectroscopic data, and pharmacological properties are reported.

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Authors and Affiliations

  1. Chemistry Department, Zagazig University, Zagazig, Egypt

    Nabil H. Ouf

  2. National Research Center, Applied Organic Chemistry Department, Cairo, Dokki, Egypt

    Abd El-Galil E. Amr & Ahmed A. Fayed

Authors
  1. Nabil H. Ouf
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  2. Abd El-Galil E. Amr
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  3. Ahmed A. Fayed
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Correspondence to Abd El-Galil E. Amr.

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Ouf, N., Amr, AG. & Fayed, A. Synthesis, Reactions, and Pharmacological Activities of Some Pyrimidines Using (N-Methylindolyl)acetic Acid as Synthon. Monatsh Chem 139, 281–287 (2008). https://doi.org/10.1007/s00706-007-0781-4

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  • DOI: https://doi.org/10.1007/s00706-007-0781-4

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