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Biological Studies of Some 2,4-Dichloro-5-fluorophenyl Containing Triazolothiadiazoles

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Summary.

A series of dichlorofluorophenyl containing triazolothiadiazoles were obtained by cyclocondensation of triazole with substituted benzoic, aryloxyacetic, and anilinoacetic acids using POCl3 as cyclizing agent. The structures of the newly synthesized compounds were characterized and confirmed by IR, 1H NMR, mass spectra, and elemental analysis. Selected compounds were screened for their antitubercular activity against Mycobacterium tuberculosis. The compound bearing 2,4-dichloro-5-fluorophenyl moiety at position 3, and 6 of the triazolothiadiazole showed excellent activity in vitro primary screening. Compounds with 3-chloro-4-fluorophenyl and 4-fluorophenoxymethyl moieties at position 6 of the triazolothiadiazole showed very good analgesic activity. Triazolothiadiazole with 4-chlorophenyl, 4-fluoro-3-phenoxyphenyl, and 2,4-dichloro-5-fluorophenyl moieties showed excellent antimicrobial activity against the tested strains at 6.25 μg cm−3 concentrations.

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Authors and Affiliations

  1. Department of Chemistry, Mangalore University, Mangalagangothri, India

    Mari Sithambaram Karthikeyan, Bantwal Shivarama Holla & Balakrishna Kalluraya

  2. Department of Biochemistry, K.S. Hegde Medical Academy, Deralakatte, India

    Nalilu Suchetha Kumari

Authors
  1. Mari Sithambaram Karthikeyan
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  2. Bantwal Shivarama Holla
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  3. Balakrishna Kalluraya
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  4. Nalilu Suchetha Kumari
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Correspondence to Mari Sithambaram Karthikeyan.

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Karthikeyan, M., Holla, B., Kalluraya, B. et al. Biological Studies of Some 2,4-Dichloro-5-fluorophenyl Containing Triazolothiadiazoles. Monatsh. Chem. 138, 1309–1316 (2007). https://doi.org/10.1007/s00706-007-0718-y

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