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Pentamidine Analogs: Syntheses, Structures in Solid State by 13C CP/MAS NMR Spectroscopy, and X-Ray Crystallography and their Preliminary Biological Screening Against Human Cancer

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Summary.

The synthesis of four new 1,5-bis(4-amidinophenoxy)-3-oxapentane analogs is described. The structures of the obtained bis-amidines and bis-nitriles in the solid state are evaluated on the basis of 13C CP/MAS NMR spectra and theoretical calculations at DFT level. A single crystal X-ray diffraction structure is presented for 1,5-bis(4-amidinophenoxy)-3-oxapentane. A preliminary anticancer assay against three cell lines is also given.

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Correspondence to Dorota Maciejewska.

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Maciejewska, D., Kaźmierczak, P., Żabiński, J. et al. Pentamidine Analogs: Syntheses, Structures in Solid State by 13C CP/MAS NMR Spectroscopy, and X-Ray Crystallography and their Preliminary Biological Screening Against Human Cancer. Monatsh. Chem. 137, 1225–1240 (2006). https://doi.org/10.1007/s00706-006-0515-z

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  • DOI: https://doi.org/10.1007/s00706-006-0515-z

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