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Outbreak of severe pseudorabies virus infection in pig-offal-fed farmed mink in Liaoning Province, China

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Abstract

An outbreak of severe pseudorabies virus (PRV) infection in farmed mink occurred in northern China in late 2014, causing significant economic losses in the local fur industry. Here, we report the first case of a PRV outbreak in mink in northeastern China, caused by feeding farmed mink with raw pork or organs contaminated by PRV. Mink infected with virulent PRV exhibited diarrhea, neurologic signs, and higher mortality, which can be misdiagnosed as highly pathogenic mink enteritis virus (MEV), canine distemper virus (CDV), and food poisoning. However, these were excluded as causative agents by PCR or bacteria isolation. The duration of disease was 3–7 days, and the mortality rate was 80–90%. PRV was characterized using indirect immunofluorescence assays (IFA) and electron microscopy (EM). Phylogenetic analysis based on full-length genome sequences and those of individual genes of this novel virus strain showed that it clustered in an independent branch with several other PRV isolates from China.

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Acknowledgements

We wish to express our sincere gratitude to Ning-Yi Jin at the Institute of Military Veterinary, Academy of Military Medical Sciences, for excellent technical assistance. This work was supported by the Technology and Development Program of Jilin Province (20150520127JH).

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    Authors and Affiliations

    1. Division of Infectious Diseases of Special Economic Animals, State Key Laboratory for Molecular Biology of Special Economic Animals, Institute of Special Animal and Plant Sciences, Chinese Academy of Agricultural Sciences, Changchun, 130122, China

      Hao Liu, Xin-Tong Li, Bo Hu, Xiao-Yu Deng, Lei Zhang, Shi-Zhen Lian, Hai-Ling Zhang, Shuang Lv, Xiang-Hong Xue, Rong-Guang Lu, Ning Shi & Xi-Jun Yan

    2. Department of Veterinary Medicine, Agriculture College of Yanbian University, Yanji, China

      Ming-Hao Yan

    3. Medical College of Yanbian University, Yanji, China

      Peng-Peng Xiao

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    1. Hao Liu
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    Correspondence to Xi-Jun Yan.

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    The authors declare no conflicts of interest.

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    This article does not contain any studies performed by any of the authors on human participants or animals.

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    Informed consent was obtained from all individual participants (mink farmers) mentioned in the study.

    Additional information

    H. Liu and X.-T. Li contributed to the work equally and should be regarded as co-first authors.

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    Cite this article

    Liu, H., Li, XT., Hu, B. et al. Outbreak of severe pseudorabies virus infection in pig-offal-fed farmed mink in Liaoning Province, China. Arch Virol 162, 863–866 (2017). https://doi.org/10.1007/s00705-016-3170-7

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    • DOI: https://doi.org/10.1007/s00705-016-3170-7

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