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IFN-stimulated gene expression is independent of the IFNL4 genotype in chronic HIV-1 infection

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Abstract

This study aimed to evaluate the association between the IFNL4 rs368234815 (ΔG/TT) dinucleotide polymorphism and the IFN response during chronic HIV-1 infection. We carried out genotyping analysis and measured the expression of IFN-stimulated genes (ISGs) (myxovirus resistance protein A [MxA], ISG15, ISG56, apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like [APOBEC] 3F and APOBEC3G) on peripheral blood mononuclear cells collected from naïve and HAART-treated HIV-1-infected patients. There were no statistically significant differences in endogenous ISGs mRNA levels among HIV-1-positive patients bearing different IFNL4 genotypes, suggesting that ISG expression is independent of the IFNL4 genotype in HIV-1 infection.

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Authors and Affiliations

  1. Laboratory of Virology, Department of Molecular Medicine, Istituto Pasteur Italia-Cenci Bolognetti Fondazione, Sapienza University of Rome, Viale di Porta Tiburtina n° 28, 00185, Rome, Italy

    Katia Monteleone, Giuseppe Corano Scheri, Maura Statzu, Carla Selvaggi, Francesca Falasca, Ombretta Turriziani, Guido Antonelli & Carolina Scagnolari

  2. Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy

    Noemi Giustini & Gabriella d’Ettorre

  3. Department of Clinical Medicine, Sapienza University of Rome, Rome, Italy

    Ivano Mezzaroma

Authors
  1. Katia Monteleone
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  2. Giuseppe Corano Scheri
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  3. Maura Statzu
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  4. Carla Selvaggi
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  5. Francesca Falasca
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  6. Noemi Giustini
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  7. Ivano Mezzaroma
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  8. Ombretta Turriziani
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  9. Gabriella d’Ettorre
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  10. Guido Antonelli
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  11. Carolina Scagnolari
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Corresponding author

Correspondence to Carolina Scagnolari.

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Funding

This study was funded by a grant to Carolina Scagnolari from Istituto Pasteur Italia, Fondazione Cenci Bolognetti (Research program funding 2013–2015, Prot. 55/2013), and Sapienza University of Rome (Ricerche Universitarie, anno 2015, C26A15WTF4).

Conflict of interest

All the authors declare that they have no conflict of interest.

Ethical approval

The study was approved by the ethics committee of the Policlinico Umberto I Hospital, “Sapienza” University of Rome, and informed consent was obtained from all subjects.

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Monteleone, K., Scheri, G.C., Statzu, M. et al. IFN-stimulated gene expression is independent of the IFNL4 genotype in chronic HIV-1 infection. Arch Virol 161, 3263–3268 (2016). https://doi.org/10.1007/s00705-016-3016-3

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  • DOI: https://doi.org/10.1007/s00705-016-3016-3

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