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Phylogenetic analysis of porcine circovirus type 2 (PCV2) isolates from China with high homology to PCV2c

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Abstract

Porcine circovirus type 2 (PCV2) is an important emerging pathogen that has been causatively associated with multifactorial disease syndromes in pigs and other species. It has a worldwide distribution and causes significant economic losses in the swine industry. Its genome is dynamically evolving through recombination and mutation, and the circulating genotypes of PCV2 strains in Asia are PCV2a, PCV2b and PCV2d. In this study, 12 PCV isolates were evaluated and identified by amplification, sequencing, and phylogenetic analysis, and the results revealed a new monophyletic group of PCV in China. More importantly, three of these isolates shared high homology within the ORF1 region with a strain of genotype PCV2c that was detected only in Denmark. Phylogeographic analysis of these isolates suggested that the isolates may have arisen in Denmark and that they were then transported to China.

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Acknowledgments

This study was financially supported by the grant from the National “Twelfth Five-Year” High Technology Research and Development Program (2011AA10A213), the Agricultural Science and Technology Innovation Program (CAAS-ASTIP-2014-ISAPS), and Key Technology R&D Program of Jilin Province (20140204073NY).

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Authors and Affiliations

  1. State Key Laboratory for Molecular Biology of Special Economic Animals, Institute of Special Economic Animal and Plant Sciences, Chinese Academy of Agricultural Sciences, 4899 Juye Street, Changchun, 130112, Jilin, People’s Republic of China

    Xing Liu, Feng-Xue Wang, Hong-Wei Zhu, Na Sun & Hua Wu

  2. Sinovet (Beijing) Biotechnology Co., Ltd., Beijing, People’s Republic of China

    Hua Wu

Authors
  1. Xing Liu
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  2. Feng-Xue Wang
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  3. Hong-Wei Zhu
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  4. Na Sun
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  5. Hua Wu
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Corresponding author

Correspondence to Hua Wu.

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Funding

This study was funded by 2011AA10A213, CAAS-ASTIP-2014-ISAPS, 20140204073NY.

Conflict of interest

Author Xing Liu declares that she has no conflict of interest. Author Feng-Xue Wang declares that she has no conflict of interest. Author Hong-Wei Zhu declares that he has no conflict of interest. Author Na Sun declares that she has no conflict of interest. Author Hua Wu declares that he has no conflict of interest.

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This article does not contain any studies with human participants or animals performed by any of the authors.

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Liu, X., Wang, FX., Zhu, HW. et al. Phylogenetic analysis of porcine circovirus type 2 (PCV2) isolates from China with high homology to PCV2c. Arch Virol 161, 1591–1599 (2016). https://doi.org/10.1007/s00705-016-2823-x

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  • DOI: https://doi.org/10.1007/s00705-016-2823-x

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