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Polymorphisms in the retinoic acid-1 like-receptor family of genes and their association with clinical outcome of dengue virus infection

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Abstract

Polymorphisms in the DDX58 and IFIH1 genes, which code for the retinoic acid inducible gene-1 protein and myeloid differentiation factor (MDA) 5, were investigated in 120 dengue (DEN) cases (88 dengue fever [DF] cases and 32 dengue hemorrhagic fever [DHF] cases) and 109 healthy controls (HCs) to investigate their association with dengue. The results revealed a lower carrier frequency of the DDX58 rs3205166 G allele in DEN than in HCs and a higher frequency of the DDX58 rs669260 T/C genotype in DHF than in DF cases (P = 0.043, OR with 95 % CI 3.358 [1.038-10.861]). This suggests that polymorphisms in DDX58 gene influence the clinical outcome of DENV infection.

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Acknowledgments

The authors thank all the study subjects for their participation in the study. The authors acknowledge Mr. Anand Singh, Mrs. Bachal RV, Mr. Kakade MB and Mrs. Asha Bhagat for their help in collection and testing of the samples for dengue.

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Authors and Affiliations

  1. Dengue Group, National Institute of Virology (Indian Council of Medical Research), 20A, Dr Ambedkar Road, Pune, Maharashtra, India

    K. Alagarasu, R. S. Memane & P. S. Shah

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  1. K. Alagarasu
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  2. R. S. Memane
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  3. P. S. Shah
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Correspondence to K. Alagarasu.

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Alagarasu, K., Memane, R.S. & Shah, P.S. Polymorphisms in the retinoic acid-1 like-receptor family of genes and their association with clinical outcome of dengue virus infection. Arch Virol 160, 1555–1560 (2015). https://doi.org/10.1007/s00705-015-2417-z

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  • DOI: https://doi.org/10.1007/s00705-015-2417-z

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