An overnight switch to ropinirole therapy in patients with Parkinson's disease
- Cite this article as:
- Canesi, M., Antonini, A., Mariani, C. et al. J Neural Transm (1999) 106: 925. doi:10.1007/s007020050212
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Patients with Parkinson's disease (n = 68) switched from per-golide or bromocriptine to ropinirole overnight (dose equivalence ratios – 1 : 6 and 10 : 6, respectively). The activities of daily living score for the Unified Parkinson's Disease Rating Scale (UPDRS) was significantly improved 4 weeks after the bromocriptine–ropinirole switch. All other UPDRS scores, including that for the side-effect component, were not significantly different after either switch. Overnight switching may be a safe therapeutic approach that may reduce hospitalisation and related socio-economic costs.