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Association between cognitive impairment and urinary dysfunction in Parkinson’s disease

  • Neurology and Preclinical Neurological Studies - Original Article
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Abstract

Urinary dysfunction (UD) is a common non-motor feature of Parkinson’s disease (PD), and might be secondary to neurodegeneration involving cortical and subcortical brain areas. The possible link between UD and cognitive deficits has never been examined in frontal cortex impairment, and is still not completely understood in PD. In the present study, 94 PD patients underwent a comprehensive motor, cognitive and non-motor assessment. It was shown that 55.3% of patients reported UD, of which 17% needed specific urological treatment. Patients who reported UD performed worse on global cognition (PANDA, p = .05), visuo-constructive functions (CERAD/praxis, p = .03; and Figure Test, p = .03), and instrumental activities of daily living functions (IADL, p = .03), than patients without UD. The group with UD medication performed worse on global cognition (PANDA, p = .02) and visuo-constructive functions (CERAD/praxis, p = .05; CERAD/praxis recall, p = .05) than the UD group without medication, independent of anticholinergic treatment effect. Our findings suggest an association between cognitive impairment and UD in PD independent from symptomatic treatment.

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    Authors and Affiliations

    1. German Center of Neurodegenerative Diseases (DZNE), Bonn, Germany

      Zuzanna Tkaczynska, Sara Becker, Susanne Gräber-Sultan & Inga Liepelt-Scarfone

    2. Hertie Institute for Clinical Brain Research, Department of Neurodegeneration, University of Tuebingen, Tuebingen, Germany

      Zuzanna Tkaczynska, Andrea Pilotto, Sara Becker, Susanne Gräber-Sultan, Daniela Berg & Inga Liepelt-Scarfone

    3. Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy

      Andrea Pilotto

    4. Department of Neurology, Christian-Albrechts-University of Kiel, Kiel, Germany

      Daniela Berg

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    1. Zuzanna Tkaczynska
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    Correspondence to Inga Liepelt-Scarfone.

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    DPV Research Grant 2014/2015

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    D. Berg and I. Liepelt-Scarfone contributed to this work equally.

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    Tkaczynska, Z., Pilotto, A., Becker, S. et al. Association between cognitive impairment and urinary dysfunction in Parkinson’s disease. J Neural Transm 124, 543–550 (2017). https://doi.org/10.1007/s00702-017-1690-2

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    • DOI: https://doi.org/10.1007/s00702-017-1690-2

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