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Therapies for Parkinson’s diseases: alternatives to current pharmacological interventions

  • High Impact Review in Neuroscience, Neurology or Psychiatry - Review Article
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Abstract

Parkinson’s disease (PD) is the second most common neurodegenerative disorder caused by the selective and progressive loss of dopaminergic neurons in the substantia nigra pars compacta. Although PD has been heavily researched, the precise etiology and pathogenesis for PD are still inconclusive. Consequently, current pharmacological treatments for PD are largely symptomatic rather than preventive and there is still no cure for this disease nowadays. Moreover, nonmotor symptoms caused by intrinsic PD pathology or side effects induced by currently used pharmacological interventions are gaining increasing attention and urgently need to be treated due to their influence on quality of life. As ancient traditional healing systems, Tai Chi, Yoga, acupuncture and natural products have long been considered as complementary or alternative therapeutic options for PD. Recently, several newly developed non-pharmacological therapeutic strategies, including deep brain stimulation, repetitive transcranial magnetic stimulation, near-infrared light, gene therapy and cell replacement therapy, have also been suggested to give benefits to relieve parkinsonian symptoms. This review will summarize and update the therapeutic potential and the most recent research progresses of these traditional and modern therapeutic options and highlight their clinical meaning for the therapy of not only PD but also other neurodegenerative diseases.

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Acknowledgments

This review was supported by grants from the National Natural Science Foundation of China (81370470 and 81430021), the Program for Liaoning Innovative Research Team in University (LT2015009), the Scientific Research Fund of Liaoning Provincial Education Department (L2015145) and Liaoning Science and Technology Project (2015225008).

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    1. Center for Translational Research on Neurological Diseases, The First Affiliated Hospital, Dalian Medical University, Dalian, 116021, China

      Song Li, Jie Dong, Cheng Cheng & Weidong Le

    2. Collaborative Innovation Center for Brain Science, The First Affiliated Hospital, Dalian Medical University, Dalian, 116011, China

      Weidong Le

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    1. Song Li
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    S. Li and J. Dong contributed equally to this work.

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    Li, S., Dong, J., Cheng, C. et al. Therapies for Parkinson’s diseases: alternatives to current pharmacological interventions. J Neural Transm 123, 1279–1299 (2016). https://doi.org/10.1007/s00702-016-1603-9

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