Abstract
Angiotensin-converting enzyme (ACE) has shown altered activity in patients with neurological diseases. An insertion/deletion (I/D) polymorphism of the ACE gene encoding angiotensin-converting enzyme has been reported to be associated with the risk for Alzheimer’s disease (AD), and is generally considered to be a disorder primarily affecting memory. We conducted a case–control study in a sample composed of 85 sporadic AD patients and 90 age- and sex-matched controls to investigate the possible effect of the polymorphism and cognitive profile. Our data revealed an association between the ACE polymorphism and AD risk. There was a significant difference in the ACE allele or genotype frequencies between cases and controls. The D/D genotype showed an increased risk for AD and in the amnestic group and the effect was independent on ApoE genotypes.
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Acknowledgments
This work was funded by the Ministry of Higher Education and Scientific Research in Tunisia. Faculté de médecine, Tunis. Research Laboratory “temporal lobe pathology” CHU Charles Nicolle, Tunis. This project is conducted within the framework of MOBIDOC-Post doc as specified in PASRI program, funded by the EU and managed by the ANPR.
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Achouri-Rassas, A., Ali, N.B., Cherif, A. et al. Association between ACE polymorphism, cognitive phenotype and APOE E4 allele in a Tunisian population with Alzheimer disease. J Neural Transm 123, 317–321 (2016). https://doi.org/10.1007/s00702-015-1468-3
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DOI: https://doi.org/10.1007/s00702-015-1468-3