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Is cognitive stability in Parkinson’s disease a predictable phenomenon? A 5-year follow-up study

  • Neurology and Preclinical Neurological Studies - Short communication
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An Erratum to this article was published on 06 November 2015

Abstract

Cognitive disturbances are integral to the course of PD but the rate of cognitive decline remains largely unpredictable. The aim of this study was to determine the clinical features associated with “cognitive stability”. Fifty-four patients (32 with normal cognition and 22 featuring MCI) were recruited in 2009 and re-evaluated after a mean time of 4.7 years; all patients underwent a detailed neuropsychological and clinical evaluation. A proportion of 61 % of patients (19 with normal cognition and 14 with MCI) remained cognitive stable, whereas 39 % had reduced cognitive reserve. After multivariate analysis, only the preservation of visuo-spatial domain was predictive of cognitive stability.

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References

  • Anang JB, Gagnon JF, Bertrand JA, Romenets SR, Latreille V, Panisset M et al (2014) Predictors of dementia in Parkinson disease: a prospective cohort study. Neurology 83(14):1253–1260

    Article  PubMed Central  PubMed  Google Scholar 

  • Burn DJ, Barker RA (2013) Mild cognitive impairment in Parkinson’s disease: millstone or milestone? Pract Neurol 13(2):68–69

    Article  PubMed  Google Scholar 

  • Calamia M, Markon K, Denburg NL, Tranel D (2011) Developing a short form of Benton’s Judgment of Line Orientation Test: an item response theory approach. Clin Neuropsychol 25(4):670–684

    Article  PubMed Central  PubMed  Google Scholar 

  • Di Battista ME, Giustini P, Bernardi S, Stirpe P, Vanacore N, Meco G (2011) A simplified algorithm may lead to overestimate dementia in PD. A clinical and epidemiological study using criteria for PD-D proposed by the Movement Disorders Task Force. J Neural Transm 118(11):1609–1612

    Article  PubMed  Google Scholar 

  • Emre M, Aarsland D, Brown R, Burn DJ, Duyckaerts C, Mizuno Y et al (2007) Clinical diagnostic criteria for dementia associated with Parkinson’s disease. Mov Disord 22(12):1689–1707

    Article  PubMed  Google Scholar 

  • Korczyn AD (2013) Mild cognitive impairment in Parkinson’s disease. J Neural Transm 120(4):517–521

    Article  PubMed  Google Scholar 

  • Litvan I, Goldman JG, Tröster AI, Schmand BA, Weintraub D, Petersen RC et al (2012) Diagnostic criteria for mild cognitive impairment in Parkinson’s disease: Movement Disorder Society Task Force guidelines. Mov Disord 27(3):349–356

    Article  PubMed Central  PubMed  Google Scholar 

  • Pagonabarraga J, Kulisevsky J (2012) Cognitive impairment and dementia in Parkinson’s disease. Neurobiol Dis 46(3):590–596

    Article  PubMed  Google Scholar 

  • Petersen RC, Smith GE, Waring SC, Ivnik RJ, Tangalos EG, Kokmen E (1999) Mild cognitive impairment: clinical characterization and outcome. Arch Neurol 56:303–308

    Article  CAS  PubMed  Google Scholar 

  • Poletti M, Frosini D, Ceravolo R, Bonuccelli U (2012) Mild cognitive impairment in De Novo Parkinson’s disease according to movement disorder guidelines. Mov Disord 27(13):1706

    Article  PubMed  Google Scholar 

  • Szeto JY, Mowszowski L, Gilat M, Walton CC, Naismith SL, Lewis SJ (2015) Assessing the utility of the Movement Disorder Society Task Force Level 1 diagnostic criteria for mild cognitive impairment in Parkinson’s disease. Parkinsonism Relat Disord 21(1):31–35

    Article  PubMed  Google Scholar 

  • Williams-Gray CH, Evans JR, Goris A, Foltynie T, Ban M, Robbins TW et al (2009) The distinct cognitive syndromes of Parkinson’s disease: 5 year follow-up of the CamPaIGN cohort. Brain 132(11):2958–2969

    Article  PubMed  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Neurology and Psychiatry, University of Rome “Sapienza”, C.I.M.S. Centro Interdipartimentale Malattie Sociali, Rome, Italy

    Maria Elena Di Battista, Alfonso Rubino, Marcella Valente, Patrizia Giustini, Nicola Vanacore & Giuseppe Meco

Authors
  1. Maria Elena Di Battista
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  2. Alfonso Rubino
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  3. Marcella Valente
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  4. Patrizia Giustini
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  5. Nicola Vanacore
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  6. Giuseppe Meco
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Correspondence to Giuseppe Meco.

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Di Battista, M.E., Rubino, A., Valente, M. et al. Is cognitive stability in Parkinson’s disease a predictable phenomenon? A 5-year follow-up study. J Neural Transm 122, 1703–1706 (2015). https://doi.org/10.1007/s00702-015-1440-2

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  • DOI: https://doi.org/10.1007/s00702-015-1440-2

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