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Mesolimbic dopaminergic dysfunction in Parkinson’s disease depression: evidence from a 123I-FP-CIT SPECT investigation

  • Neurology and Preclinical Neurological Studies - Short communication
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Abstract

We investigated the striatal and extrastriatal DAT availability (SPM8) by [123I]FP-CIT-SPECT in 15 PD patients with depression and 35 PD patients without depression. A cluster with significant (p < 0.05) lower tracer binding in PD with depression was found in left cingulate cortex, persistent after correction for age, disease severity and duration, and inversely correlated with depression scores (r −0.336, p < 0.05). Our data indicate a significant association between PD depression and cingulate dopaminergic denervation supporting the dopaminergic hypothesis of PD depression.

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Authors and Affiliations

  1. Neurology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Via Roma, 67-56126, Pisa, Italy

    D. Frosini, E. Unti, C. Del Gamba, U. Bonuccelli & R. Ceravolo

  2. Nuclear Medicine Unit, Department of Translational Research and of New Surgical and Medical Technologies, University of Pisa, Pisa, Italy

    F. Guidoccio, G. Puccini & D. Volterrani

Authors
  1. D. Frosini
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  2. E. Unti
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  3. F. Guidoccio
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  4. C. Del Gamba
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  5. G. Puccini
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  6. D. Volterrani
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  7. U. Bonuccelli
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  8. R. Ceravolo
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Corresponding author

Correspondence to R. Ceravolo.

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Frosini, D., Unti, E., Guidoccio, F. et al. Mesolimbic dopaminergic dysfunction in Parkinson’s disease depression: evidence from a 123I-FP-CIT SPECT investigation. J Neural Transm 122, 1143–1147 (2015). https://doi.org/10.1007/s00702-015-1370-z

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  • DOI: https://doi.org/10.1007/s00702-015-1370-z

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