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Acetyl-L-carnitine and oxaloacetate in post-treatment against LTP impairment in a rat ischemia model. An in vitro electrophysiological study

  • Neurology and Preclinical Neurological Studies - Original Article
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Abstract

A high proportion of research relating to cerebral ischemia focuses on neuroprotection. The application of compounds normally present in the organism is popular, because they do not greatly influence the synaptic activity by receptor modulation, and can be administered without serious side effects. Oxaloacetate (OxAc) and acetyl-L-carnitine (ALC) are such favorable endogenous molecules. ALC can exert a protective effect by improving the energy state of the neurons under ischemic conditions. A promising neuroprotective strategy is glutamate scavenging, which can be achieved by the intravenous administration of OxAc. This study involved the possible protective effects of ALC and OxAc in different post-treatment protocols against long-term potentiation (LTP) impairment. Ischemia was induced in rats by 2-vessel occlusion, which led to a decreased LTP relative to the control group. High-dose (200 mg/kg) ALC or OxAc post-treatment resulted in a higher potentiation relative to the 2VO group, but it did not reach the control level, whereas low-dose ALC (100 mg/kg) in combination with OxAc completely restored the LTP function. Many previous studies have concluded that ALC can be protective only as pretreatment. The strategy described here reveals that ALC can also be neuroprotective when utilized as post-treatment against ischemia.

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Acknowledgments

This work was supported by grants from OTKA K105077, Hungarian Brain Research Program KTIA-13-NAP-A-III/9 and TÁMOP 4.2.2-A-11/KONV-2012-0052. This research was realized in the frames of TÁMOP 4.2.4 A/2-11-1-2012-0001 “National Excellence Program”—Elaborating and operating an inland student and researcher personal support system”. The project was subsidized by the European Union and co-financed by the European Social Fund.

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The authors declare that they have no conflict of interest.

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Correspondence to J. Toldi.

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Kocsis, K., Knapp, L., Mészáros, J. et al. Acetyl-L-carnitine and oxaloacetate in post-treatment against LTP impairment in a rat ischemia model. An in vitro electrophysiological study. J Neural Transm 122, 867–872 (2015). https://doi.org/10.1007/s00702-014-1343-7

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  • DOI: https://doi.org/10.1007/s00702-014-1343-7

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