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Fatty acids rehabilitated long-term neurodegenerative: like symptoms in olfactory bulbectomized rats

  • Translational Neurosciences - Original Article
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Abstract

Our previous study demonstrated that an olfactory bulbectomy in rats induced short-term, multifaceted, devastating Alzheimer’s-like effects, which included cognitive impairment, hyperactivity, hyperthermia, and increased levels of homocysteine and pro-inflammatory cytokines, including IL-17A. In addition, the rats exhibited an increase in the hyperphosphorylation of brain Tau proteins and in the number of neurofibrillary tangles. Here, we examined the long-term effects of the surgery and found that olfactory bulbectomy also rendered the rats to become anemic with brain iron overload. Additionally, a significant reduction in the membrane fluidity index in frontal cortex synaptosomes was found. Treatment with a mixture of n − 3/n − 6 of fatty acids restored the unwanted effect. The beneficial effects of fatty acids are mediated via the effects of fatty acids on the neuronal membrane structure and fluidity. These findings are similar to Alzheimer’s symptoms, which suggest this model can be used as an animal model for Alzheimer’s disease. We recommend using this model to scan potential new anti-Alzheimer’s drugs.

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Abbreviations

AD:

Alzheimer’s disease

ADHD:

Attention deficit hyperactivity disorder

EAE:

Experimental autoimmune encephalomyelitis

EFA:

Essential fatty acid

MANOVA:

Multivariate analysis of variance

OBX:

Olfactory bulbectomy

PUFA:

Polyunsaturated fatty acids

SD:

Standard deviation

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Acknowledgments

We would like to thank Dr. R. Luria for his help during the study. We also thank the Rose K. Ginsburg Chair for Research into Alzheimer’s disease and The William Farber Center for Alzheimer Research for their generous support.

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  1. Sharon Rabinovitz

    Present address: Department of Criminology, Haifa University, Haifa, Israel

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  1. Psychopharmacology Lab, Department of Psychology, Bar Ilan University, 52900, Ramat Gan, Israel

    Shlomo Yehuda

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Correspondence to Shlomo Yehuda.

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Yehuda, S., Rabinovitz, S. Fatty acids rehabilitated long-term neurodegenerative: like symptoms in olfactory bulbectomized rats. J Neural Transm 122, 629–641 (2015). https://doi.org/10.1007/s00702-014-1321-0

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  • DOI: https://doi.org/10.1007/s00702-014-1321-0

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