Journal of Neural Transmission

, Volume 121, Issue 1, pp 71–78

Decreased immunoreactivities of neocortical AMPA receptor subunits correlate with motor disability in Lewy body dementias

  • Nur-Ezan Mohamed
  • David R. Howlett
  • Lu Ma
  • Paul T. Francis
  • Dag Aarsland
  • Clive G. Ballard
  • Ian G. McKeith
  • Christopher P. Chen
  • Mitchell K. P. Lai
Neurology and Preclinical Neurological Studies - Original Article

DOI: 10.1007/s00702-013-1067-0

Cite this article as:
Mohamed, NE., Howlett, D.R., Ma, L. et al. J Neural Transm (2014) 121: 71. doi:10.1007/s00702-013-1067-0
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Abstract

Dementia with Lewy bodies and Parkinson’s disease dementia are different clinical phenotypes of Lewy body dementias differentiated by the temporal relationship between parkinsonism and dementia onset. At present, it is unclear whether the glutamatergic system is affected in these disorders. In this study, we measured α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor GluA subunits in the postmortem neocortex of a cohort of prospectively studied Lewy body dementia cases, as well as age-matched controls by immunoblotting. We found losses of GluA2/3/4 immunoreactivities in Lewy body dementias which correlated with higher pre-death Hoehn and Yahr scores and with longer Parkinson’s disease duration before dementia onset, but not with dementia severity, cortical Lewy body burden, or amyloid plaque and neurofibrillary tangle burden. Our study suggests that GluA2/3/4 losses may be a neurochemical marker of motor disability in Lewy body dementias.

Keywords

AMPA receptorsLewy body dementiaNeocortexMotor functionGlutamatergic system

Supplementary material

702_2013_1067_MOESM1_ESM.pdf (103 kb)
Supplementary material 1 (PDF 103 kb)

Copyright information

© Springer-Verlag Wien 2013

Authors and Affiliations

  • Nur-Ezan Mohamed
    • 1
  • David R. Howlett
    • 3
  • Lu Ma
    • 1
  • Paul T. Francis
    • 3
  • Dag Aarsland
    • 4
    • 5
  • Clive G. Ballard
    • 3
  • Ian G. McKeith
    • 6
  • Christopher P. Chen
    • 1
    • 2
  • Mitchell K. P. Lai
    • 1
    • 2
    • 3
  1. 1.Department of Pharmacology, Yong Loo Lin School of MedicineNational University of SingaporeSingaporeSingapore
  2. 2.Memory, Aging and Cognition CentreNational University Health SystemSingaporeSingapore
  3. 3.Wolfson Centre for Age-Related DiseasesKing’s College LondonLondonUK
  4. 4.Centre for Age-Related MedicineStavanger University HospitalStavangerNorway
  5. 5.Department of Neurobiology, Care Sciences and Society, KI-Alzheimer Disease Research CentreKarolinska InstituteStockholmSweden
  6. 6.Institute for Ageing and HealthNewcastle UniversityNewcastle upon TyneUK