Reduced serotonergic functioning changes heart rate in ADHD
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- Zepf, F.D., Holtmann, M., Stadler, C. et al. J Neural Transm (2009) 116: 105. doi:10.1007/s00702-008-0146-0
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Reduced mean heart rate (HR) was shown to be a biophysiological marker for aggression, which in turn was proven to be related to changed serotonergic neurotransmission. A total of 16 ADHD-diagnosed boys were subjected to rapid tryptophan depletion (RTD) and a placebo in a double-blind within-subject crossover-design. Mean HR was assessed under RTD/placebo. Low impulsive patients behaving aggressively under RTD showed a lowered HR under RTD versus placebo. Diminished 5-HT functioning was associated with lowered HR and aggressive behaviour.