Journal of Neural Transmission

, Volume 116, Issue 1, pp 105–108

Reduced serotonergic functioning changes heart rate in ADHD

Authors

    • Department of Child and Adolescent Psychiatry and PsychotherapyGoethe University of Frankfurt am Main
  • M. Holtmann
    • Department of Child and Adolescent Psychiatry and PsychotherapyGoethe University of Frankfurt am Main
  • C. Stadler
    • Department of Child and Adolescent Psychiatry and PsychotherapyGoethe University of Frankfurt am Main
  • L. Wöckel
    • Department of Child and Adolescent Psychiatry and PsychotherapyGoethe University of Frankfurt am Main
  • F. Poustka
    • Department of Child and Adolescent Psychiatry and PsychotherapyGoethe University of Frankfurt am Main
Biological Child and Adolescent Psychiatry - Short Communication

DOI: 10.1007/s00702-008-0146-0

Cite this article as:
Zepf, F.D., Holtmann, M., Stadler, C. et al. J Neural Transm (2009) 116: 105. doi:10.1007/s00702-008-0146-0

Abstract

Reduced mean heart rate (HR) was shown to be a biophysiological marker for aggression, which in turn was proven to be related to changed serotonergic neurotransmission. A total of 16 ADHD-diagnosed boys were subjected to rapid tryptophan depletion (RTD) and a placebo in a double-blind within-subject crossover-design. Mean HR was assessed under RTD/placebo. Low impulsive patients behaving aggressively under RTD showed a lowered HR under RTD versus placebo. Diminished 5-HT functioning was associated with lowered HR and aggressive behaviour.

Keywords

ADHDHeart rateSerotoninPhysiological arousalAggressionImpulsivity

Copyright information

© Springer-Verlag 2008