Journal of Neural Transmission

, Volume 114, Issue 7, pp 919–927

Tauopathies and synucleinopathies: Do cerebrospinal fluid β-amyloid peptides reflect disease-specific pathogenesis?

  • B. Mollenhauer
  • M. Bibl
  • H. Esselmann
  • P. Steinacker
  • C. Trenkwalder
  • J. Wiltfang
  • M. Otto
Article

DOI: 10.1007/s00702-007-0629-4

Cite this article as:
Mollenhauer, B., Bibl, M., Esselmann, H. et al. J Neural Transm (2007) 114: 919. doi:10.1007/s00702-007-0629-4

Summary

To evaluate variations in amyloid beta (Aβ) peptide pattern in cerebrospinal fluid (CSF) in neurodegenerative disorders. A recently established quantitative urea-based Aβ-sodium-dodecylsulfate-polyacrylamide-gel-electrophoresis with western immunoblot (Aβ-SDS-PAGE/immunoblot) revealed a highly conserved Aβ peptide (Aβ1-37, 1-38, 1-39, 1-40, 1-42) pattern in CSF. We asked whether the variation might be useful to further elucidate the overlap between or distinctions among neurodegenerative diseases in Aβ-processing.

We used the Aβ-SDS-PAGE/immunoblot to investigate CSF for disease-specific Aβ peptide patterns. CSF samples from 96 patients with mainly clinically diagnosed Alzheimer’s disease (n = 15), progressive supranuclear palsy (n = 20), corticobasal degeneration (n = 12), Parkinson’s disease (n = 11), multiple systems atrophy (n = 18), and dementia with Lewy-bodies (n = 20) were analysed as well a comparison group (n = 19).

The Aβ peptide patterns varied between tauopathies and synucleinopathies and between all diseases and the comparison group, possibly due to the influence of tau and α-synuclein on Aβ-processing.

Keywords: Synucleinopathies, tauopathies, Alzheimer’s disease, Parkinson’s disease, cerebrospinal fluid, amyloid β peptides

Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • B. Mollenhauer
    • 1
  • M. Bibl
    • 2
  • H. Esselmann
    • 3
  • P. Steinacker
    • 4
  • C. Trenkwalder
    • 5
  • J. Wiltfang
    • 3
  • M. Otto
    • 4
  1. 1.Brigham and Women’s Hospital and Harvard Medical SchoolBostonU.S.A.
  2. 2.Department of PsychiatryUniversity of GoettingenGoettingenGermany
  3. 3.Department of Psychiatry and PsychotherapyUniversity of Erlangen-NurembergErlangenGermany
  4. 4.Department of NeurologyUniversity of UlmUlmGermany
  5. 5.University of Goettingen, Paracelsus-Elena KlinikKasselGermany