Journal of Neural Transmission

, Volume 114, Issue 7, pp 919-927

First online:

Tauopathies and synucleinopathies: Do cerebrospinal fluid β-amyloid peptides reflect disease-specific pathogenesis?

  • B. MollenhauerAffiliated withBrigham and Women’s Hospital and Harvard Medical School
  • , M. BiblAffiliated withDepartment of Psychiatry, University of Goettingen
  • , H. EsselmannAffiliated withDepartment of Psychiatry and Psychotherapy, University of Erlangen-Nuremberg
  • , P. SteinackerAffiliated withDepartment of Neurology, University of Ulm
  • , C. TrenkwalderAffiliated withUniversity of Goettingen, Paracelsus-Elena Klinik
  • , J. WiltfangAffiliated withDepartment of Psychiatry and Psychotherapy, University of Erlangen-Nuremberg
  • , M. OttoAffiliated withDepartment of Neurology, University of Ulm

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To evaluate variations in amyloid beta (Aβ) peptide pattern in cerebrospinal fluid (CSF) in neurodegenerative disorders. A recently established quantitative urea-based Aβ-sodium-dodecylsulfate-polyacrylamide-gel-electrophoresis with western immunoblot (Aβ-SDS-PAGE/immunoblot) revealed a highly conserved Aβ peptide (Aβ1-37, 1-38, 1-39, 1-40, 1-42) pattern in CSF. We asked whether the variation might be useful to further elucidate the overlap between or distinctions among neurodegenerative diseases in Aβ-processing.

We used the Aβ-SDS-PAGE/immunoblot to investigate CSF for disease-specific Aβ peptide patterns. CSF samples from 96 patients with mainly clinically diagnosed Alzheimer’s disease (n = 15), progressive supranuclear palsy (n = 20), corticobasal degeneration (n = 12), Parkinson’s disease (n = 11), multiple systems atrophy (n = 18), and dementia with Lewy-bodies (n = 20) were analysed as well a comparison group (n = 19).

The Aβ peptide patterns varied between tauopathies and synucleinopathies and between all diseases and the comparison group, possibly due to the influence of tau and α-synuclein on Aβ-processing.

Keywords: Synucleinopathies, tauopathies, Alzheimer’s disease, Parkinson’s disease, cerebrospinal fluid, amyloid β peptides