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The plasma alpha-synuclein levels in patients with Parkinson’s disease and multiple system atrophy

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Summary.

α-Synuclein, a synaptic protein of unknown function, is a major component of Lewy bodies and may play a role in the pathophysiological process of Parkinson’s disease (PD). In this study, we measured the plasma α-synuclein levels in 105 patients with PD, 38 patients with multiple system atrophy (MSA), and 51 age-matched controls. The α-synuclein level was significantly elevated in patients with PD (79.9 ± 4.0 pg/ml, p < 0.001) and in those with MSA (78.1 ± 3.5 pg/ml, p = 0.019) compared with the level in controls (76.1 ± 3.9 pg/ml). The α-synuclein level was higher in patients with PD than in those with MSA (79.9 ± 4.0 vs 78.1 ± 3.5, p = 0.016). Our study demonstrated that the α-synuclein level in plasma is elevated in patients with PD and MSA.

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Authors and Affiliations

  1. Department of Neurology, Ajou University School of Medicine, Suwon, South Korea

    P. H. Lee, H. J. Park, O. Y. Bang, I. S. Joo & K. Huh

  2. Brain Disease Research Center, Ajou University School of Medicine, Suwon, South Korea

    G. Lee

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  1. P. H. Lee
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  2. G. Lee
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  3. H. J. Park
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  4. O. Y. Bang
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  5. I. S. Joo
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  6. K. Huh
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Lee, P., Lee, G., Park, H. et al. The plasma alpha-synuclein levels in patients with Parkinson’s disease and multiple system atrophy. J Neural Transm 113, 1435–1439 (2006). https://doi.org/10.1007/s00702-005-0427-9

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  • DOI: https://doi.org/10.1007/s00702-005-0427-9

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